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      Dexamethasone otoprotection in a multidose cisplatin ototoxicity mouse model.

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          Abstract

          To develop a murine model for multidose administration of cisplatin that produces significant hearing threshold elevations and to use this model to assess the protective properties of intratympanic (IT) dexamethasone against cisplatin ototoxicity.

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          Author and article information

          Journal
          Otolaryngol Head Neck Surg
          Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
          SAGE Publications
          1097-6817
          0194-5998
          Jan 2014
          : 150
          : 1
          Affiliations
          [1 ] University of Connecticut Health Center, Department of Surgery, Division of Otolaryngology-Head & Neck Surgery, Farmington, Connecticut, USA.
          Article
          0194599813511948
          10.1177/0194599813511948
          24233060
          cca3074a-752f-42ea-8da5-26675911bded
          History

          ototoxicity,sensorineural hearing loss,murine model,cisplatin

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