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Right Ventricular Function in Cor pulmonale
Abstract
Traditionally the right ventricle has been thought to function poorly in the presence of an increased afterload. Indeed, the presence of pulmonary arterial hypertension, or cor pulmonale, has been associated with a poor prognosis in patients with hypoxic chronic obstructive pulmonary disease (COPD). Recent data suggest that right ventricular contractility as measured by the right ventricular end-systolic pressure/volume relationship is relatively normal in patients with COPD, despite the presence of pulmonary arterial hypertension if the patients are studied when clinically stable, but reduced when the patients present with oedema. Continuous oxygen therapy is the only treatment which has been shown to improve survival in patients with COPD and cor pulmonale. However, the effects of oxygen therapy may not be directly related to an improvement in cardiac function.
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174443 Cardiology 1988;75:30–40Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.