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      Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

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      Nature Medicine
      Springer Science and Business Media LLC

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          Abstract

          Tumors are like new organs and are made of multiple cell types and components. The tumor competes with the normal microenvironment to overcome antitumorigenic pressures. Before that battle is won, the tumor may exist within the organ unnoticed by the host, referred to as 'occult cancer'. We review how normal tissue homeostasis and architecture inhibit progression of cancer and how changes in the microenvironment can shift the balance of these signals to the procancerous state. We also include a discussion of how this information is being tailored for clinical use.

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          Author and article information

          Journal
          Nature Medicine
          Nat Med
          Springer Science and Business Media LLC
          1078-8956
          1546-170X
          March 2011
          March 7 2011
          March 2011
          : 17
          : 3
          : 320-329
          Article
          10.1038/nm.2328
          3569482
          21383745
          ccb68309-a99c-4c52-a770-74cbd08ba9c0
          © 2011

          http://www.springer.com/tdm

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