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      Antibiotic-induced biofilm formation.

      1
      The International journal of artificial organs
      SAGE Publications

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          Abstract

          Surface-attached colonies of bacteria known as biofilms play a major role in the pathogenesis of device-related infections. Biofilm colonies are notorious for their resistance to suprainhibitory concentrations of antibiotics. Numerous studies have shown that subminimal inhibitory concentrations of some antibiotics can act as agonists of bacterial biofilm formation in vitro, a process that may have clinical relevance. This article reviews studies demonstrating that low-dose antibiotics induce bacterial biofilm formation. These studies have provided important information about the regulation of biofilm formation and the signaling pathways involved in global gene regulation in response to cell stressors. It is still unclear whether antibiotic-induced biofilm formation contributes to the inconsistent success of antimicrobial therapy for device infections.

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          Author and article information

          Journal
          Int J Artif Organs
          The International journal of artificial organs
          SAGE Publications
          1724-6040
          0391-3988
          Sep 2011
          : 34
          : 9
          Affiliations
          [1 ] Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA. kaplanjb@umdnj.edu
          Article
          C16A6C3C-83B2-4EB5-83C8-C3EBF8ED9745
          10.5301/ijao.5000027
          22094552
          ccbdd510-4a0f-40a3-8224-1116c6343cc1
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