47
views
0
recommends
+1 Recommend
0 collections
    4
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Opioid-induced Rewards, Locomotion, and Dopamine Activation: A Proposed Model for Control by Mesopontine and Rostromedial Tegmental Neurons

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Opioids, such as morphine or heroin, increase forebrain dopamine (DA) release and locomotion, and support the acquisition of conditioned place preference (CPP) or self-administration. The most sensitive sites for these opioid effects in rodents are in the ventral tegmental area (VTA) and rostromedial tegmental nucleus (RMTg). Opioid inhibition of GABA neurons in these sites is hypothesized to lead to arousing and rewarding effects through disinhibition of VTA DA neurons. We review findings that the laterodorsal tegmental (LDTg) and pedunculopontine tegmental (PPTg) nuclei, which each contain cholinergic, GABAergic, and glutamatergic cells, are important for these effects. LDTg and/or PPTg cholinergic inputs to VTA mediate opioid-induced locomotion and DA activation via VTA M5 muscarinic receptors. LDTg and/or PPTg cholinergic inputs to RMTg also modulate opioid-induced locomotion. Lesions or inhibition of LDTg or PPTg neurons reduce morphine-induced increases in forebrain DA release, acquisition of morphine CPP or self-administration. We propose a circuit model that links VTA and RMTg GABA with LDTg and PPTg neurons critical for DA-dependent opioid effects in drug-naïve rodents.

          Related collections

          Author and article information

          Journal
          7806090
          6166
          Neurosci Biobehav Rev
          Neurosci Biobehav Rev
          Neuroscience and biobehavioral reviews
          0149-7634
          1873-7528
          30 October 2017
          23 September 2017
          December 2017
          01 December 2018
          : 83
          : 72-82
          Affiliations
          [1 ]Dept of Psychology, Loyola University Chicago
          [2 ]Robarts Research Institute University of Western Ontario
          [3 ]Dept of Neurologic Surgery, Mayo Clinic
          [4 ]Dept of Psychology, University of Toronto
          Author notes
          [# ]Corresponding Author: Stephan Steidl (Department of Psychology, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60626, United States; ssteidl@ 123456luc.edu ; Fax 773 508 8713)
          Article
          PMC5730464 PMC5730464 5730464 nihpa912514
          10.1016/j.neubiorev.2017.09.022
          5730464
          28951251
          ccc0217a-7897-468a-af58-c44ca7eff840
          History
          Categories
          Article

          acetylcholine,GABA,glutamate,addiction,laterodorsal tegmental nucleus,pedunculopontine tegmental nucleus,reward,morphine

          Comments

          Comment on this article