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      Review of current and emerging therapies in type 2 diabetes mellitus.

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      The American journal of managed care

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          Abstract

          Significant advances in the treatment of type 2 diabetes mellitus (T2DM) include the implementation of prevention efforts aimed at delaying progression of glucose intolerance to overt diabetes mellitus (DM) and the development of new classes of blood glucose-lowering medications to supplement existing therapies. While the current management approach for T2DM continues to encompass traditional drugs that focus on β-cell failure and/or insulin resistance, newer agents that target other defects (eg, incretin deficiency/resistance) are increasingly incorporated. Furthermore, the effect of therapies on associated comorbidities (eg, dyslipidemia, hypertension, obesity, hypercoagulability) has become an additional therapeutic focus. This article provides a discussion of specific pharmacologic agents, based on guidelines from the American Diabetes Association/European Association for the Study of Diabetes and relevant clinical studies. An extensive update on the newest drugs (eg, incretin-based therapies, amylin agonists) and managed care aspects of diabetes care is also included.

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          Author and article information

          Journal
          Am J Manag Care
          The American journal of managed care
          1936-2692
          1088-0224
          Jan 2012
          : 18
          : 1 Suppl
          Affiliations
          [1 ] College of Pharmacy and Allied Health Professions, St. John's University, Queens, and North Shore University Hospital, Manhasset, NY, USA. mazzolan@stjohns.edu
          Article
          46701
          22559854
          ccc4909a-bb67-42bb-8921-af2fc8ac22de
          History

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