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Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis
Yannan Fan ,
Sehrish K. Bazai ,
Fabrice Daian ,
Maria Arechederra ,
Sylvie Richelme ,
Nuri A. Temiz ,
Annie Yim ,
Bianca H. Habermann ,
Rosanna Dono ,
David A. Largaespada ,
Flavio Maina
December 2018
December 2018
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Abstract
The variety of alterations found in hepatocellular carcinoma (HCC) makes the identification
of functionally relevant genes and their combinatorial actions in tumorigenesis challenging.
Deregulation of receptor tyrosine kinases (RTKs) is frequent in HCC, yet little is
known about the molecular events that cooperate with RTKs and whether these cooperative
events play an active role at the root of liver tumorigenesis.