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      Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis

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          Abstract

          The variety of alterations found in hepatocellular carcinoma (HCC) makes the identification of functionally relevant genes and their combinatorial actions in tumorigenesis challenging. Deregulation of receptor tyrosine kinases (RTKs) is frequent in HCC, yet little is known about the molecular events that cooperate with RTKs and whether these cooperative events play an active role at the root of liver tumorigenesis.

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          Author and article information

          Journal
          Journal of Hepatology
          Journal of Hepatology
          Elsevier BV
          01688278
          December 2018
          December 2018
          Article
          10.1016/j.jhep.2018.11.027
          30529386
          © 2018

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