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      Autofeedback of Prolactin in Cultured Prolactin-Secreting Pituitary Cells

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      Hormone Research in Paediatrics

      S. Karger AG

      Prolactin, GH3 cells

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          Cultured GH<sub>3</sub> rat pituitary tumor cells which secrete prolactin (PRL) were used to study autoregulation of rat PRL (rPRL) secretion. Acute (1 h) release of rPRL by cells in monolayer culture was inhibited by ovine PRL (oPRL; 10<sup>-7</sup> and 10<sup>-8</sup> M)· Intracellular rPRL accumulation was not inhibited by exogenous oPRL. No effect of oPRL was seen during long-term (12-day) incubation of cells with oPRL (10<sup>-7</sup> to 10<sup>-9</sup> M). oPRL exerts an acute suppressive effect on rPRL release at the cellular level, but does not inhibit rPRL synthesis or long-term release.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 12
          : 6
          : 340-344
          Endocrine Research Laboratory, Veterans Administration Wadsworth Medical Center and Department of Medicine, University of California, Los Angeles, Calif.
          179140 Horm Res 1980;12:340–344
          © 1980 S. Karger AG, Basel

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          Pages: 5
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