Annika Jagodzinski , 1 , 2 , 3 , Christoffer Johansen 3 , 4 , 5 , 6 , Uwe Koch-Gromus 7 , Ghazal Aarabi 8 , Gerhard Adam 9 , Sven Anders 10 , Matthias Augustin 11 , Ramona B. der Kellen 3 , Thomas Beikler 12 , Christian-Alexander Behrendt 13 , Christian S. Betz 14 , Carsten Bokemeyer 15 , Katrin Borof 3 , Peer Briken 16 , Chia-Jung Busch 14 , Christian Büchel 17 , Stefanie Brassen 17 , Eike S. Debus 13 , Larissa Eggers 3 , Jens Fiehler 18 , Jürgen Gallinat 19 , Simone Gellißen 18 , Christian Gerloff 20 , Evaldas Girdauskas 21 , Martin Gosau 22 , Markus Graefen 23 , Martin Härter 24 , Volker Harth 25 , Christoph Heidemann 3 , Guido Heydecke 8 , Tobias B. Huber 26 , Yassin Hussein 3 , Marvin O. Kampf 3 , Olaf von dem Knesebeck 27 , Alexander Konnopka 28 , Hans-Helmut König 28 , Robert Kromer 29 , Christian Kubisch 30 , Simone Kühn 19 , Sonja Loges 15 , 34 , Bernd Löwe 31 , Gunnar Lund 9 , Christian Meyer 2 , 32 , Lina Nagel 3 , Albert Nienhaus 33 , Klaus Pantel 34 , Elina Petersen 3 , Klaus Püschel 10 , Hermann Reichenspurner 21 , Guido Sauter 35 , Martin Scherer 36 , Katharina Scherschel 2 , 32 , Ulrich Schiffner 12 , Renate B. Schnabel 1 , 2 , Holger Schulz 24 , Ralf Smeets 22 , Vladislavs Sokalskis 3 , Martin S. Spitzer 29 , Claudia Terschüren 25 , Imke Thederan 23 , Tom Thoma 3 , Götz Thomalla 20 , Benjamin Waschki 1 , 2 , 38 , Karl Wegscheider 6 , Jan-Per Wenzel 1 , 3 , Susanne Wiese 3 , Birgit-Christiane Zyriax 2 , 37 , Tanja Zeller 1 , 2 , 3 , Stefan Blankenberg 1 , 2
8 November 2019
Epidemiology, Prospective cohort study, Risk factors, Prevention, Coronary heart disease, Stroke, Dementia, Cancer, Health care, Vascular diseases, Oral health, Psychiatric and psychosomatic disorders, Ocular diseases, Respiratory diseases, Obesity, Nutrition, Lifestyle, Sexual dysfunction, Survivorship, Resilience, MRI imaging, Cardiac MRI, Brain MRI, Health service research, Hamburg
The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several important risk and prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 and 74 years of age from the general population of Hamburg, Germany, are taking part in an extensive baseline assessment at one dedicated study center. Participants undergo 13 validated and 5 novel examinations primarily targeting major organ system function and structures including extensive imaging examinations. The protocol includes validate self-reports via questionnaires regarding lifestyle and environmental conditions, dietary habits, physical condition and activity, sexual dysfunction, professional life, psychosocial context and burden, quality of life, digital media use, occupational, medical and family history as well as healthcare utilization. The assessment is completed by genomic and proteomic characterization. Beyond the identification of classical risk factors for major chronic diseases and survivorship, the core intention is to gather valid prevalence and incidence, and to develop complex models predicting health outcomes based on a multitude of examination data, imaging, biomarker, psychosocial and behavioral assessments. Participants at risk for coronary artery disease, atrial fibrillation, heart failure, stroke and dementia are invited for a visit to conduct an additional MRI examination of either heart or brain. Endpoint assessment of the overall sample will be completed through repeated follow-up examinations and surveys as well as related individual routine data from involved health and pension insurances. The study is targeting the complex relationship between biologic and psychosocial risk and resilience factors, chronic disease, health care use, survivorship and health as well as favorable and bad prognosis within a unique, large-scale long-term assessment with the perspective of further examinations after 6 years in a representative European metropolitan population.