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      Urinary elimination kinetics of acephate and its metabolite, methamidophos, in urine after acute ingestion.

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          Abstract

          Acephate (AP) is a widely available organophosphorus (OP) insecticide considered to have low mammalian toxicity. In plants and insects, AP is metabolized extensively to methamidophos (MP), a more potent OP insecticide. The limited mammalian metabolism of AP to MP has been studied in laboratory rat models and suggests that initial formation of MP from AP may inhibit further formation. No case reports of human ingestion with urine AP and MP levels have been previously published.

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          Author and article information

          Journal
          J Med Toxicol
          Journal of medical toxicology : official journal of the American College of Medical Toxicology
          1556-9039
          1556-9039
          Jun 2009
          : 5
          : 2
          Affiliations
          [1 ] Emory University; Georgia Poison Center, Atlanta, GA, USA.
          Article
          3550324
          19415590
          cce0672d-276f-492f-9aee-f5008951d8fe
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