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      Chitotriosidase and soluble IL-2 receptor: comparison of two markers of sarcoidosis severity.

      Scandinavian Journal of Clinical and Laboratory Investigation
      Biological Markers, blood, Female, Health, Hexosaminidases, metabolism, Humans, Male, Middle Aged, Receptors, Interleukin-2, Sarcoidosis, enzymology, pathology, Smoking, Solubility

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          Abstract

          Sarcoidosis is a multisystemic granulomatous disease with an unpredictable clinical course characterized by accumulation of activated proliferating T lymphocytes and mononuclear phagocytes in affected organs. The aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients followed at the Sarcoidosis Regional Centre in Siena and to analyse chitotriosidase and sIL-2R concentrations in serum of these patients in order to understand their potential as disease markers. Chitotriosidase and sIL-2R concentrations in serum of sarcoidosis patients were found to be significantly higher than in healthy controls (p<0.01) and a positive correlation between the two markers was documented for the first time. Moreover, chitotriosidase and sIL-2R were expressed differently in different radiographic stages of the disease. Chitotriosidase and sIL-2R are two markers of sarcoidosis of different origin, the values of which show a correlation in these patients; they are easily detectable in serum and could be useful clinical markers of progression.

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          Author and article information

          Journal
          18609101
          10.1080/00365510701854975

          Chemistry
          Biological Markers,blood,Female,Health,Hexosaminidases,metabolism,Humans,Male,Middle Aged,Receptors, Interleukin-2,Sarcoidosis,enzymology,pathology,Smoking,Solubility

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