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      Reduced Erythrocyte Defense Mechanisms against Free Radical Toxicity in Patients with Chronic Renal Failure

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          In this study, activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) enzymes were determined in the erythrocytes from patients with chronic renal failure (CRF) and from healthy subjects. In the conservative drug management group and intermittent ambulatory peritoneal dialysis group, CAT activity was lower than in the control group. However, SOD and GSH-Px activities of these groups were not statistically different from the control values. In the continuous ambulatory peritoneal dialysis group and the hemodialysis group, SOD, GSH-Px and CAT activities were lower than control values. In the patient groups, correlation coefficients between the enzyme activities were also found to be different from the control values. Results suggested that enzymatic antioxidant defense mechanisms were suppressed in the erythrocytes from the patients with CRF, in particular in the erythrocytes from those who were under hemodialysis and continuous ambulatory peritoneal dialysis management. It is proposed that reduced antioxidant defense mechanisms in the erythrocytes is one of the important factors leading to peroxidation in the membrane lipid structure of the erythrocytes and thereby to hemolysis and anemia in the patients with CRF.

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          Author and article information

          S. Karger AG
          16 December 2008
          : 66
          : 1
          : 76-80
          aDepartment of Biochemistry and bIbn-i Sina Hospital, Department of Nephrology, Medical Faculty, Ankara University, Ankara, Turkey
          187770 Nephron 1994;66:76–80
          © 1994 S. Karger AG, Basel

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          Pages: 5
          Original Paper


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