Optical coherence tomography angiography characteristics of acute retinal arterial occlusion

Abstract

Background

To characterize the vascular changes in eyes within the acute phase of retinal arterial occlusion (RAO) by optical coherence tomography angiography (OCT-A) imaging.

Methods

This was a retrospective, observational study. Nineteen patients with RAO (symptom onset within 7 days) and 19 age and sex-matched normal control individuals were included. A comprehensive ophthalmic examination and OCT-A examination were conducted for all the patients.

Results

The vessel density of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and area with a width of 300 μm around the FAZ (FD-300) was significantly reduced in RAO patients compared with that in the fellow eyes and normal control eyes. The vessel density of the SCP of RAO fellow eyes was significantly lower than that of the normal control eyes (all P < 0.05). Though no difference was observed in the FAZ of RAO eyes compared with that of fellow eyes and normal control eyes, the acircularity index (AI) of the FAZ was significantly increased in RAO eyes ( P < 0.05). Central macular thickness (CMT) was correlated with best-corrected visual acuity in central retinal arterial occlusion (CRAO) patients ( r = 0.626, P = 0.024). In BRAO eyes, the vessel density of the RAO-affected hemifield was significantly reduced compared with that of the unaffected hemifield ( P < 0.05). Radial peripapillary plexus (RPC) vessel density was reduced, accompanied by retinal nerve fiber layer (RNFL) thinning in 3 available CRAO patients.

Conclusions

As a valuable noninvasive imaging tool, OCT-A provides deeper and more detailed vascular information that extends our understanding of the vasculature alterations in acute RAO.

Electronic supplementary material

The online version of this article (10.1186/s12886-019-1152-8) contains supplementary material, which is available to authorized users.