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      Public health risk of antimicrobial resistance transfer from companion animals.

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          Abstract

          Antimicrobials are important tools for the therapy of infectious bacterial diseases in companion animals. Loss of efficacy of antimicrobial substances can seriously compromise animal health and welfare. A need for the development of new antimicrobials for the therapy of multiresistant infections, particularly those caused by Gram-negative bacteria, has been acknowledged in human medicine and a future corresponding need in veterinary medicine is expected. A unique aspect related to antimicrobial resistance and risk of resistance transfer in companion animals is their close contact with humans. This creates opportunities for interspecies transmission of resistant bacteria. Yet, the current knowledge of this field is limited and no risk assessment is performed when approving new veterinary antimicrobials. The objective of this review is to summarize the current knowledge on the use and indications for antimicrobials in companion animals, drug-resistant bacteria of concern among companion animals, risk factors for colonization of companion animals with resistant bacteria and transmission of antimicrobial resistance (bacteria and/or resistance determinants) between animals and humans. The major antimicrobial resistance microbiological hazards originating from companion animals that directly or indirectly may cause adverse health effects in humans are MRSA, methicillin-resistant Staphylococcus pseudintermedius, VRE, ESBL- or carbapenemase-producing Enterobacteriaceae and Gram-negative bacteria. In the face of the previously recognized microbiological hazards, a risk assessment tool could be applied in applications for marketing authorization for medicinal products for companion animals. This would allow the approval of new veterinary medicinal antimicrobials for which risk levels are estimated as acceptable for public health.

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          Author and article information

          Journal
          J. Antimicrob. Chemother.
          The Journal of antimicrobial chemotherapy
          Oxford University Press (OUP)
          1460-2091
          0305-7453
          April 01 2017
          : 72
          : 4
          Affiliations
          [1 ] Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
          [2 ] Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
          [3 ] National Veterinary Institute, Uppsala, Sweden.
          [4 ] Danish Health and Medicines Authority, Copenhagen, Denmark.
          [5 ] Scientific Institute of Public Health, Brussels, Belgium.
          [6 ] National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
          [7 ] Royal Veterinary College, University of London, London, UK.
          [8 ] Faculty of Veterinary Medicine, Complutense University, Madrid, Spain.
          [9 ] Veterinary Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
          [10 ] Agence Nationale de Sécurité Sanitaire (ANSES), Fougères, France.
          [11 ] Veterinary Laboratories Agency, New Haw, UK.
          [12 ] Health Protection Agency, London, UK.
          [13 ] European Medicines Agency, London, UK.
          [14 ] Facultat de Veterinària, UAB, Cerdanyola del Vallès, Spain.
          [15 ] Veterinary Medicines Directorate, Addlestone, UK.
          [16 ] Läkemedelsverket, Uppsala, Sweden.
          Article
          dkw481
          10.1093/jac/dkw481
          27999066

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