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      Effects of Bacillus subtilis on hepatic lipid metabolism and oxidative stress response in grass carp ( Ctenopharyngodon idellus) fed a high-fat diet

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          Abstract

          Bacillus subtilis is widely used in aquaculture as a probiotic. However, few studies have been conducted to examine the eff ect of B. subtilis on liver lipid metabolism. A total of 135 healthy grass carp (50.24 ± 1.38 g) were randomly divided into three groups: control (Con), high-fat diet (HF), and high-fat diet + B. subtilis (HF + B. subtilis), and fed for 8 weeks. The results showed that compared with the HF group, the weight gain rate (WGR) significantly increased ( P < 0.05) and the hepatic lipid content, serum low-density lipoprotein cholesterol (LDL-C), and aspartate aminotransferase (AST) decreased in the group supplemented with B. subtilis ( P < 0.05). Moreover, the hepatic mRNA expression of fatty acid synthase ( FAS) was significantly down-regulated and the carnitine palmitoyl transferases ( CPT1α1a) were up-regulated in the HF + B. subtilis group compared to the HF group ( P < 0.05), respectively. Additionally, in the HF + B. subtilis group, glutathione (GSH) significantly increased ( P < 0.05), while hydrogen peroxide (H 2O 2) and malondialdehyde (MDA) contents significantly decreased compared to the HF group ( P < 0.05). B. subtilis may reduce the hepatic lipid content by inhibiting its synthesis and promoting β-oxidation of fatty acids. B. subtilis may also alleviate dyslipidaemia and prevent oxidative damage in the liver caused by the high-fat diet of grass carp. Hence, dietary supplementation with B. subtilis shows promise as a therapeutic or preventive tool against fatty liver disease.

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          Author and article information

          Journal
          MLST
          Marine Life Science & Technology
          Springer (China )
          2096-6490
          2662-1746
          01 February 2020
          08 October 2019
          : 2
          : 1
          : 50-59
          Affiliations
          1College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China
          2Hubei Engineering Technology Research Center for Aquatic Animal Disease Control and Prevention, Wuhan 430070, China
          3Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan 430070, China
          4Hubei Provincial Engineering Laboratory for Pond Aquaculture, Wuhan 430070, China
          Author notes
          *Corresponding author: Zhixin Wu, E-mail: wuzhixin@ 123456mail.hzau.edu.cn ; wuzhixin229@ 123456163.com
          Article
          s42995-019-00005-2
          10.1007/s42995-019-00005-2
          © 2019 Ocean University of China
          Product
          Self URI (journal-page): https://www.springer.com/journal/42995
          Categories
          Research Paper

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