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      Differential functional brain network connectivity during visceral interoception as revealed by independent component analysis of fMRI time‐series


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          Influential theories of brain‐viscera interactions propose a central role for interoception in basic motivational and affective feeling states. Recent neuroimaging studies have underlined the insula, anterior cingulate, and ventral prefrontal cortices as the neural correlates of interoception. However, the relationships between these distributed brain regions remain unclear. In this study, we used spatial independent component analysis (ICA) and functional network connectivity (FNC) approaches to investigate time course correlations across the brain regions during visceral interoception. Functional magnetic resonance imaging (fMRI) was performed in thirteen healthy females who underwent viscerosensory stimulation of bladder as a representative internal organ at different prefill levels, i.e., no prefill, low prefill (100 ml saline), and high prefill (individually adapted to the sensations of persistent strong desire to void), and with different infusion temperatures, i.e., body warm (∼37°C) or ice cold (4–8°C) saline solution. During Increased distention pressure on the viscera, the insula, striatum, anterior cingulate, ventromedial prefrontal cortex, amygdalo‐hippocampus, thalamus, brainstem, and cerebellar components showed increased activation. A second group of components encompassing the insula and anterior cingulate, dorsolateral prefrontal and posterior parietal cortices and temporal‐parietal junction showed increased activity with innocuous temperature stimulation of bladder mucosa. Significant differences in the FNC were found between the insula and amygdalo‐hippocampus, the insula and ventromedial prefrontal cortex, and the ventromedial prefrontal cortex and temporal‐parietal junction as the distention pressure on the viscera increased. These results provide new insight into the supraspinal processing of visceral interoception originating from an internal organ. Hum Brain Mapp 36:4438–4468, 2015. © 2015 Wiley Periodicals, Inc.

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          Author and article information

          Hum Brain Mapp
          Hum Brain Mapp
          Human Brain Mapping
          John Wiley and Sons Inc. (Hoboken )
          07 August 2015
          November 2015
          : 36
          : 11 ( doiID: 10.1002/hbm.v36.11 )
          : 4438-4468
          [ 1 ] Clinic for Neuroradiology, University Hospital Zurich Switzerland
          [ 2 ] Department of Information Technology and Electrical Engineering, Institute for Biomedical Engineering Federal Institute of Technology (ETH) Zurich Switzerland
          [ 3 ] Neuro‐Urology Spinal Cord Injury Center and Research, Balgrist University Hospital Zurich Switzerland
          [ 4 ] Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior University of California, Los Angeles (UCLA) California
          [ 5 ] Neuroscience Center Zurich, University and ETH Zurich Switzerland
          [ 6 ] Department of Experimental Psychology University of Oxford Oxford United Kingdom
          [ 7 ] Department of Health Sciences and Technology Neural Control of Movement Laboratory ETH Zurich Switzerland
          [ 8 ] Center for MR‐Research, University Children's Hospital Zurich Switzerland
          Author notes
          [*] [* ]Correspondence to: Behnaz Jarrahi, MS. Eng., Dr. Sc., University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90095. E‐mail: behnazj@ 123456ucla.edu
          PMC6869370 PMC6869370 6869370 HBM22929
          © 2015 Wiley Periodicals, Inc.
          : 08 December 2014
          : 20 July 2015
          : 27 July 2015
          Page count
          Pages: 31
          Funded by: Swiss National Science Foundation
          Award ID: 135774
          Research Article
          Research Articles
          Custom metadata
          November 2015
          Converter:WILEY_ML3GV2_TO_JATSPMC version:5.7.2 mode:remove_FC converted:15.11.2019

          salience,bladder,self‐referential,limbic,alliesthesia,homeostasis,fMRI,prefrontal,insula,visceral sensation


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