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      Efficacy of a fixed-dose combination of trandolapril-verapamil in obese hypertensive patients resistant to monotherapy.

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          Abstract

          This paper sought to determine if the fixed-dose combination of trandolapril and verapamil is effective in the treatment of hypertensive obese patients resistant to monotherapy. Thirty-six hypertensive obese patients uncontrolled by monotherapy were given the combination of trandolapril-verapamil (2/180 mg) for 12 weeks. Before and after taking the drug, they self-measured their blood pressure. Patients experienced a significant reduction of blood pressure (from 178 +/- 18/100 +/- 12 mm Hg to 135 +/- 14/76 +/- 7 mm Hg, p < 0.001). Eighty percent of patients reached therapeutic goals; one patient suffered from headaches and one had constipation. it was determined that the combination of trandolapril-verapamil is effective and safe for the management of hypertension in obese patients uncontrolled by monotherapy.

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          Author and article information

          Journal
          Clin. Exp. Hypertens.
          Clinical and experimental hypertension (New York, N.Y. : 1993)
          Informa UK Limited
          1064-1963
          1064-1963
          Oct 2006
          : 28
          : 7
          Affiliations
          [1 ] Hypertension Clinic, Hospital General de Ticomán SS DF, Mexico City, México. clinhta@hotmail.com
          Article
          L5G81440X886T8K0
          10.1080/08860220600946087
          17060060

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