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      Modified intention-to-treat analysis did not bias trial results.

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          Abstract

          To investigate whether analysis of the modified intention-to-treat (mITT) population with postrandomization exclusion of patients from analysis is associated with biased estimates of treatment effect compared to the conservative intention-to-treat (ITT) population.

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          Author and article information

          Journal
          J Clin Epidemiol
          Journal of clinical epidemiology
          Elsevier BV
          1878-5921
          0895-4356
          Apr 2016
          : 72
          Affiliations
          [1 ] Department of Rheumatology, Musculoskeletal Statistics Unit, The Parker Institute, Frederiksberg Hospital, Nordre Fasanvej 57, 2000 Copenhagen, Denmark.
          [2 ] Department of Medicine, David Geffen School of Medicine, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
          [3 ] Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
          [4 ] Clinical Epidemiology Program, Department of Epidemiology and Community Medicine, Ottawa Hospital Research Institute, University of Ottawa, Room 3105, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada.
          [5 ] Department of Clinical Epidemiology & Biostatistics, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada.
          [6 ] Department of Rheumatology, The Parker Institute, Frederiksberg Hospital, Nordre Fasanvej 57, 2000 Copenhagen, Denmark.
          [7 ] Department of Rheumatology, Musculoskeletal Statistics Unit, The Parker Institute, Frederiksberg Hospital, Nordre Fasanvej 57, 2000 Copenhagen, Denmark. Electronic address: Robin.Christensen@regionh.dk.
          Article
          S0895-4356(15)00506-5
          10.1016/j.jclinepi.2015.11.003
          26562052
          cd220c98-2d0f-48db-bdf1-69f79cf0d67b

          Rheumatoid arthritis,Bias,Biological disease-modifying antirheumatic drugs (DMARD),Epidemiology,Intention-to-treat analysis,Meta-analysis

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