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      The Pineal Gland and the Effect of Neonatal Administration of Androgen upon the Development of Spontaneous Salt and Water Intake in Female Rats

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          Abstract

          The effect of pinealectomy (PX) and sham-pinealectomy (SPX) on the calculated concentration of NaCl in the total volume of fluid drunk per day ([NaCl]<sub>i</sub>) in female rats offered a free choice between water and 3% NaCl solution was measured. In normal rats the [NaCl]<sub>i</sub> increases after attainment of sexual maturity. The increase can be accelerated by neonatal PX. Neonatal ‘masculinization’ of female rats by testosterone propionate (TP2) removes the increase of [NaCl]<sub>i</sub> in adult females and suppresses the acceleration due to PX. Neonatal SPX interferes with this decreasing effect of TP2 in adult female rats. The role of the pineal gland in the regulation of water and salt intake is discussed in relation to sex differences, sexual maturation and neonatal stress.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1975
          1975
          20 March 2008
          : 18
          : 2
          : 137-143
          Affiliations
          Institute of Physiology, Czechoslovak Academy of Sciences, Prague
          Article
          122393 Neuroendocrinology 1975;18:137–143
          10.1159/000122393
          1165847
          © 1975 S. Karger AG, Basel

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          Pages: 7
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