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      Biogenic Synthesis of NiO Nanoparticles Using Areca catechu Leaf Extract and Their Antidiabetic and Cytotoxic Effects


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          Nanoworld is an attractive sphere with the potential to explore novel nanomaterials with valuable applications in medicinal science. Herein, we report an efficient and ecofriendly approach for the synthesis of Nickel oxide nanoparticles (NiO NPs) via a solution combustion method using Areca catechu leaf extract. As-prepared NiO NPs were characterized using various analytical tools such as powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and UV-Visible spectroscopy (UV-Vis). XRD analysis illustrates that synthesized NiO NPs are hexagonal structured crystallites with an average size of 5.46 nm and a hexagonal-shaped morphology with slight agglomeration. The morphology, size, and shape of the obtained material was further confirmed using SEM and TEM analysis. In addition, as-prepared NiO NPs have shown potential antidiabetic and anticancer properties. Our results suggest that the inhibition of α-amylase enzyme with IC 50 value 268.13 µg/mL may be one of the feasible ways through which the NiO NPs exert their hypoglycemic effect. Furthermore, cytotoxic activity performed using NiO NPs exhibited against human lung cancer cell line (A549) proved that the prepared NiO NPs have significant anticancer activity with 93.349 μg/mL at 50% inhibition concentration. The biological assay results revealed that NiO NPs exhibited significant cytotoxicity against human lung cancer cell line (A549) in a dose-dependent manner from 0–100 μg/mL, showing considerable cell viability. Further, the systematic approach deliberates the NiO NPs as a function of phenolic extracts of A. catechu with vast potential for many biological and biomedical applications.

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            The green synthesis, characterization and evaluation of the biological activities of silver nanoparticles synthesized from Iresine herbstii leaf aqueous extracts.

            Silver has been used since time immemorial in different chemical form to treat burns, wounds and several infections caused by pathogenic bacteria. Advancement of biological process of nanoparticles synthesis is evolving into a key area of nanotechnology. The current study deals with the synthesis, characterization of silver nanoparticles using Iresine herbstii and evaluation of their antibacterial, antioxidant and cytotoxic activity. The reaction mixture turned to brownish gray color after 7 days of incubation and exhibits an absorbance peak around 460 nm characteristic of Ag nanoparticle. Scanning electron microscopy (SEM) and EDX analysis showed silver nanoparticles were pure and polydispersed and the size were ranging from 44 to 64 nm. X-ray diffraction (XRD) studies revealed that most of the nanoparticles were cubic and face centered cubic in shape. Fourier transform infrared spectroscopy (FTIR) showed nanoparticles were capped with plant compounds. Biosynthesized silver nanoparticles showed potent antibacterial activity against human pathogenic bacteria. Phytosynthesized nanoparticles exhibited strong antioxidant activity as well as cytotoxicity against HeLa cervical cell lines. The approach of green synthesis seems to be cost efficient, eco-friendly and easy alternative to conventional methods of silver nanoparticles synthesis. The powerful bioactivity demonstrated by the synthesized silver nanoparticles leads towards the clinical use as antibacterial, antioxidant as well as cytotoxic agent.
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              Green synthesis of multifunctional zinc oxide (ZnO) nanoparticles using Cassia fistula plant extract and their photodegradative, antioxidant and antibacterial activities


                Author and article information

                Role: Academic Editor
                22 April 2021
                May 2021
                : 26
                : 9
                : 2448
                [1 ]Research Centre, Department of Chemistry, GM Institute of Technology, Davangere 577 006, Karnataka, India; shwethaur@ 123456gmail.com (S.U.R.); rajithcr91@ 123456gmail.com (R.K.C.R.); kiranmsafare@ 123456gmail.com (K.M.S.)
                [2 ]Department of Chemistry, R L Science Institute, Belagavi 590 001, Karnataka, India; lathamschem97@ 123456gmail.com
                [3 ]Department of Metallurgy and Materials Engineering, Malawi Institute of Technology, Malawi University of Science and Technology, Limbe P.O. Box 5916, Malawi; rveerapur@ 123456must.ac.mw
                [4 ]Faculty of Nature and Life Sciences, Earth and Universe Sciences, University of Tlemcen, Tlemcen 13000, Algeria; lamraouig@ 123456gmail.com
                [5 ]Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia; aalkhuraif@ 123456ksu.edu.sa
                [6 ]Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; aelgorban@ 123456ksu.edu.sa (A.M.E.); assyed@ 123456ksu.edu.sa (A.S.)
                [7 ]Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru 570 015, Karnataka, India; chandans@ 123456jssuni.edu.in
                [8 ]Department of Sciences, Amrita School of Arts and Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru 570 026, Karnataka, India
                Author notes
                [* ]Correspondence: virupaxb@ 123456gmail.com (V.S.B.); shivachemist@ 123456gmail.com (S.P.K.)
                Author information
                © 2021 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/).

                : 18 December 2020
                : 10 March 2021

                areca catechu,nio nps,tem,antidiabetic activity,anticancer potential


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