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      Genetics of Alzheimer disease.

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          Abstract

          Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1, and PSEN2) and 1 genetic risk factor (APOEε4 allele). Identification of these genes has led to a number of animal models that have been useful to study the pathogenesis underlying AD. In this article, we provide an overview of the clinical and genetic features of AD.

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          Author and article information

          Journal
          J Geriatr Psychiatry Neurol
          Journal of geriatric psychiatry and neurology
          SAGE Publications
          0891-9887
          0891-9887
          Dec 2010
          : 23
          : 4
          Affiliations
          [1 ] Department of Medicine, University of Washington School of Medicine, Seattle, WA 98108, USA.
          Article
          23/4/213 NIHMS268644
          10.1177/0891988710383571
          3044597
          21045163
          cd32272b-927a-4a72-80de-2ac8600de8d9
          History

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