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      Metabolism of Progesterone by the Brain and Pituitary Gland of Subhuman Primates

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          Abstract

          The major metabolites from incubat¡on of <sup>14</sup>C-progesterone with 700 × g cell-free homogenates of cerebral cortex, hypothalamus and pituitary gland from 5 male ba-boons and 4 male rhesus monkeys were 5 α-pregnane-3,20-dione and 2O α-dihydroprogesterone. Both compounds were identified by their chromatographic properties, derivative formation, reverse isotope dilution methods and recrystallization to constant specific activities. The activities (pmoles h<sup>–1</sup> mg<sup>–1</sup>) of the 20 α-hydroxysteroid dehydrogenase, highest in the cerebral cortex of the subhuman primates, exceeded those of the 5 α-reductase and did not change in males with sexual maturity. These data from subhuman primates are contrasted to those from rats in which the 5 α-reductase activity exceeded approximately 2-fold that of the dehydrogenase in the 3 neural areas studied. In addition, 5 β-pregnane-3,20-dione was isolated and identified from the pooled radioactive metabolites from incubation of the baboon neural tissues.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1974
          1974
          25 March 2008
          : 15
          : 5
          : 281-289
          Affiliations
          Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Wash.
          Article
          122318 Neuroendocrinology 1974;15:281–289
          10.1159/000122318
          4431558
          © 1974 S. Karger AG, Basel

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          Page count
          Pages: 9
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