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      Impairment of paravascular clearance pathways in the aging brain.

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          Abstract

          In the brain, protein waste removal is partly performed by paravascular pathways that facilitate convective exchange of water and soluble contents between cerebrospinal fluid (CSF) and interstitial fluid (ISF). Several lines of evidence suggest that bulk flow drainage via the glymphatic system is driven by cerebrovascular pulsation, and is dependent on astroglial water channels that line paravascular CSF pathways. The objective of this study was to evaluate whether the efficiency of CSF-ISF exchange and interstitial solute clearance is impaired in the aging brain.

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          Author and article information

          Journal
          Ann. Neurol.
          Annals of neurology
          1531-8249
          0364-5134
          Dec 2014
          : 76
          : 6
          Affiliations
          [1 ] Center for Translational Neuromedicine, University of Rochester School of Medicine, Rochester, NY.
          Article
          NIHMS628368
          10.1002/ana.24271
          25204284
          cd3df448-fd2d-47a4-ad53-29085dcf0561
          © 2014 American Neurological Association.
          History

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