0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Non-Conventional Growth Hormone Therapy in Turner Syndrome: The United States Experience

      Hormone Research in Paediatrics

      S. Karger AG

      Growth hormone, Turner syndrome, Growth, Short stature

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Beginning in 1983, 71 girls with Turner syndrome were enrolled in a prospective, randomized study of human growth hormone (hGH), alone and in combination with oxandrolone; 4-5 patient-year data are currently available on 66 subjects. While the annual growth rate of the untreated control group (expressed as a Z score for untreated Turner girls) was – 0.1 SD, the annual Turner growth rate Z scores for girls receiving hGH alone were + 3.1, + 2.0, + 1.5 and +2.9 SD for years 1-4, respectively (hGH was given daily in year 4). Mean annual Turner growth rate Z scores for subjects on combination therapy with oxandrolone were +6.6, +4.3, +3.0 and +2.7 SD for years 1-4, respectively. The mean height for the 20 subjects ≧ 16 years of age is 150 cm.

          Related collections

          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-5289-9
          978-3-318-01976-6
          1663-2818
          1663-2826
          1990
          1990
          02 December 2008
          : 33
          : 2-4
          : 137-143
          Affiliations
          Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif., USA
          Article
          181497 Horm Res 1990;33:137–143
          10.1159/000181497
          2210618
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          IV. Update on Growth Hormone Therapy

          Comments

          Comment on this article