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      Non-Conventional Growth Hormone Therapy in Turner Syndrome: The United States Experience

      Hormone Research in Paediatrics

      S. Karger AG

      Growth hormone, Turner syndrome, Growth, Short stature

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          Beginning in 1983, 71 girls with Turner syndrome were enrolled in a prospective, randomized study of human growth hormone (hGH), alone and in combination with oxandrolone; 4-5 patient-year data are currently available on 66 subjects. While the annual growth rate of the untreated control group (expressed as a Z score for untreated Turner girls) was – 0.1 SD, the annual Turner growth rate Z scores for girls receiving hGH alone were + 3.1, + 2.0, + 1.5 and +2.9 SD for years 1-4, respectively (hGH was given daily in year 4). Mean annual Turner growth rate Z scores for subjects on combination therapy with oxandrolone were +6.6, +4.3, +3.0 and +2.7 SD for years 1-4, respectively. The mean height for the 20 subjects ≧ 16 years of age is 150 cm.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 33
          : 2-4
          : 137-143
          Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif., USA
          181497 Horm Res 1990;33:137–143
          © 1990 S. Karger AG, Basel

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          Page count
          Pages: 7
          IV. Update on Growth Hormone Therapy


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