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      Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOEε4-negative subgroup.

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          Abstract

          Recently, the association between PICALM rs3851179 polymorphism and Alzheimer's disease (AD) was investigated in the Chinese population by 3 independent studies. However, both allele and genotype tests failed to reveal any association. The association was identified only in the APOEε4-negative subgroup. We think that the failure to replicate the association may be because of the relatively small sample size. In this research, we reinvestigated the association using all the samples from these 3 studies (n = 2486, and 1202 cases and 1284 control subjects). We failed to replicate this association between the rs3851179 polymorphism and AD in all samples and the APOEε4-negative subgroup. Our results indicate that rs3851179 may not be an AD susceptibility locus in the Chinese population and the APOEε4-negative subgroup.

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          Author and article information

          Journal
          Neurobiol. Aging
          Neurobiology of aging
          Elsevier BV
          1558-1497
          0197-4580
          Apr 2013
          : 34
          : 4
          Affiliations
          [1 ] Institute of Neurology, Guangdong Medical College, District of Xiashan, Zhanjiang, Guangdong, China. liuguiyou1981@163.com
          Article
          S0197-4580(12)00437-X
          10.1016/j.neurobiolaging.2012.08.015
          23040034
          cd70f001-5e36-4b27-86d5-35cb2e905ccf
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