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      Determining a minimal important change in a disease-specific Quality of Life Questionnaire.

      1 , , ,
      Journal of clinical epidemiology
      Elsevier BV

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          Abstract

          This study was carried out to determine whether the minimal important difference, in evaluative quality of life instruments which use a 7-point scale, is similar across individual domains and for both improvement and deterioration. Thirty nine adults with asthma were studied, using an 8 week cohort with assessments at 0, 4 and 8 weeks. The outcomes were the Asthma Quality of Life Questionnaire and global rating of change. For overall asthma-specific quality of life and for all individual domains (activities, emotions, symptoms), the minimal important difference of quality of life score per item was very close to 0.5 (range: 0.42-0.58); differences of approximately 1.0 represented a moderate change (range: 0.77-1.51); differences greater than 1.5 represented large changes. Changes for improvement and deterioration were very similar. The changes in quality of life score that represent a minimal important difference are very similar to those observed for other evaluative instruments. The observation that the minimal important difference is consistent across domains and for both improvement and deterioration will facilitate interpretation of results of studies examining quality of life.

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          Author and article information

          Journal
          J Clin Epidemiol
          Journal of clinical epidemiology
          Elsevier BV
          0895-4356
          0895-4356
          Jan 1994
          : 47
          : 1
          Affiliations
          [1 ] Department of Clinical Epidemiology and Biostatistics, McMaster University Medical Centre, Hamilton, Ontario, Canada.
          Article
          0895-4356(94)90036-1
          10.1016/0895-4356(94)90036-1
          8283197
          cd82e292-0b75-4fab-b935-90d6678fad32
          History

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