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      Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease.

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          Abstract

          The chronic lung diseases, asthma and chronic obstructive pulmonary disease (COPD), are common affecting over 500 million people worldwide and causing substantial morbidity and mortality. Asthma is typically associated with Th2-mediated eosinophilic airway inflammation, in contrast to neutrophilic inflammation observed commonly in COPD. However, there is increasing evidence that the eosinophil might play an important role in 10-40% of patients with COPD. Consistently in both asthma and COPD a sputum eosinophilia is associated with a good response to corticosteroid therapy and tailored strategies aimed to normalize sputum eosinophils reduce exacerbation frequency and severity. Advances in our understanding of the multistep paradigm of eosinophil recruitment to the airway, and the consequence of eosinophilic inflammation, has led to the development of new therapies to target these molecular pathways. In this article we discuss the mechanisms of eosinophilic trafficking, the tools to assess eosinophilic airway inflammation in asthma and COPD during stable disease and exacerbations and review current and novel anti-eosinophilic treatments.

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          Author and article information

          Journal
          Ther Adv Chronic Dis
          Therapeutic advances in chronic disease
          2040-6223
          2040-6223
          Jan 2016
          : 7
          : 1
          Affiliations
          [1 ] Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity and Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, UK.
          [2 ] Institute for Lung Health, Clinical Science Wing, University Hospital of Leicester, Leicester LE3 9QP, UK.
          Article
          10.1177_2040622315609251
          10.1177/2040622315609251
          26770668
          cd87aafb-7490-4ae8-8273-a1100a686db3
          History

          ACOS,COPD,anti-CRTh2,anti-IL-13,anti-IL4R,anti-IL5,asthma,biomarker,corticosteroid,eosinophil

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