Antidepressant-like effects of cortical deep brain stimulation coincide with pro-neuroplastic adaptations of serotonin systems.

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Abstract

Cortical deep brain stimulation (DBS) is a promising therapeutic option for treatment-refractory depression, but its mode of action remains enigmatic. Serotonin (5-HT) systems are engaged indirectly by ventromedial prefrontal cortex (vmPFC) DBS. Resulting neuroplastic changes in 5-HT systems could thus coincide with the long-term therapeutic activity of vmPFC DBS.

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Journal

Journal ID (iso-abbrev): Biol Psychiatry

Title: Biological psychiatry

Publisher: Elsevier BV

ISSN (Electronic): 1873-2402

ISSN (Print): 0006-3223

Publication date (Electronic): Aug 01 2014

Volume: 76

Issue: 3

Affiliations

[1 ] Department of Psychiatry, Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.

[2 ] Department of Psychiatry, Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Neuroscience Graduate Group, Perelman School of Medicine, Philadelphia, Pennsylvania.

[3 ] Department of Psychiatry, Perelman School of Medicine, Philadelphia, Pennsylvania.

[4 ] Department of Neuroscience Graduate Group, Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Anesthesiology, Children's Hospital of Philadelphia Research Institute and Perelman School of Medicine, Philadelphia, Pennsylvania.

[5 ] Department of Psychiatry, Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Neuroscience Graduate Group, Perelman School of Medicine, Philadelphia, Pennsylvania. Electronic address: bertonol@mail.med.upenn.edu.

Article

Mid ID: NIHMS552726 Publisher Item ID: S0006-3223(13)01130-X

DOI: 10.1016/j.biopsych.2013.12.009

PMC ID: 4072754

PubMed ID: 24503468

SO-VID: cd87e830-77ca-4442-bc49-75b46cb375d5

History

Keywords: Deep brain stimulation,depression,dorsal raphe,neuroplasticity,prefrontal cortex,social defeat

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Keywords: Deep brain stimulation, depression, dorsal raphe, neuroplasticity, prefrontal cortex, social defeat

Antidepressant-like effects of cortical deep brain stimulation coincide with pro-neuroplastic adaptations of serotonin systems.

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Karger: Neurology and Neuroscience

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