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      Presence of Positive Feedback in Males with Klinefelter’s Syndrome

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          Abstract

          This study examined the effect of 17β-estradiol (E<sub>2</sub>) on basal and luteinizing hormone (LH)-releasing hormone (LHRH)-stimulated gonadotropin secretion in 9 patients with Klinefelter’s syndrome. Intramuscular injection of E<sub>2</sub> (10 µg/kg/day during 5 days) induced a rapid decrease in follicle-stimulating hormone (FSH) and LH levels. The maximum suppression was observed on day 7 (D7) for FSH [median 9.7 mlU/ml (range 4.6-37.8) vs. 21.7 mlU/ml (range 12.2-56.9)] and on D2 for LH [median 13.6 mlU/ml (range 6.8-25.2) vs. 21.2 mlU/ml (range 13-54.7)]. E<sub>2</sub> concentrations rose and reached their peak values on D3 [median 723 pmol/l (range 517-1,247.8) vs. 110.1 pmol/l (range 68.6-227.5) on DO]. These changes were followed by a subsequent rise in LH on D4 [36.7 mlU/ml (range 19.4-77.7)]. LH response to LHRH was higher during E<sub>2</sub> treatment: median value of absolute peaks: 156.3 mlU/ml (range 56.7-188.6) on D4 vs. 64 mlU/ml (range 38.9-131) on DO. These results demonstrate the presence of a positive feedback in patients with Klinefelter’s syndrome.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1990
          1990
          02 December 2008
          : 33
          : 6
          : 244-247
          Affiliations
          Service d’Endocrinologie, Hôpital de Bains Romains, Alger, Algérie
          Article
          181526 Horm Res 1990;33:244–247
          10.1159/000181526
          2127042
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 4
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          Original Paper

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