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      In VitroCombination of Voriconazole and Miltefosine against Clinically Relevant Molds

      , , , , , ,

      Antimicrobial Agents and Chemotherapy

      American Society for Microbiology

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          ABSTRACT

          Invasive infections caused by filamentous fungi are a major threat for immunocompromised patients. Innate/acquired resistance to antifungal drugs might necessitate combination therapies. We assessed the potential combination of voriconazole with miltefosine, an original drug with antifungal activity against 33 clinically relevant mold isolates, including both azole-susceptible and -resistant Aspergillus. Using complete inhibition as an endpoint, interactions were indifferent for 32/33 isolates. An alternative 50% inhibition endpoint showed synergistic interactions for 14/33 isolates. Antagonism was absent.

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          Author and article information

          Journal
          Antimicrobial Agents and Chemotherapy
          Antimicrob. Agents Chemother.
          American Society for Microbiology
          0066-4804
          1098-6596
          October 16 2014
          November 2014
          November 2014
          September 08 2014
          : 58
          : 11
          : 6996-6998
          Article
          10.1128/AAC.03212-14
          © 2014
          Product
          Self URI (article page): https://aac.asm.org/content/58/11/6996

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