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      Pharmacology of oleanolic acid and ursolic acid

      Journal of Ethnopharmacology

      Elsevier BV

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          Abstract

          Oleanolic acid and ursolic acid are triterpenoid compounds that exist widely in food, medicinal herbs and other plants. This review summarizes the pharmacological studies on these two triterpenoids. Both oleanolic acid and ursolic acid are effective in protecting against chemically induced liver injury in laboratory animals. Oleanolic acid has been marketed in China as an oral drug for human liver disorders. The mechanism of hepatoprotection by these two compounds may involve the inhibition of toxicant activation and the enhancement of the body defense systems. Oleanolic acid and ursolic acid have also been long-recognized to have antiinflammatory and antihyperlipidemic properties in laboratory animals, and more research is warranted to develop a therapy for patients. Recently, both compounds have been noted for their antitumor-promotion effects, which are stimulating additional research in this field. Oleanolic acid and ursolic acid are relatively non-toxic, and have been used in cosmetics and health products. The possible mechanisms for the pharmacological effects and the prospects for these two compounds are discussed.

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          Author and article information

          Journal
          Journal of Ethnopharmacology
          Journal of Ethnopharmacology
          Elsevier BV
          03788741
          December 1995
          December 1995
          : 49
          : 2
          : 57-68
          Article
          10.1016/0378-8741(95)90032-2
          8847885
          cd9ef10a-a691-4f0a-9545-7e67466a42f4
          © 1995

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