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      Synthesis and micellar mimic properties of bile acid trimers.

      Bioorganic & Medicinal Chemistry Letters
      Alkynes, chemistry, Azides, Bile Acids and Salts, chemical synthesis, Click Chemistry, Humans, Micelles, Molecular Conformation

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          Abstract

          Two fan-shaped bile acid trimers have been synthesized via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) 'click chemistry', and their extraction experiments of cresol red sodium (CR) and pyrene were investigated in the polar and non-polar solvents, respectively. The transmission electron microscopy (TEM) results showed that the homogenous hollow capsules formed with the diameter size range of 40-70 nm in a solution of water and acetone. Thus the amphiphilicity of fan-shaped bile acid trimers might be used as the promising candidate in biological and drug delivery applications. Copyright © 2013 Elsevier Ltd. All rights reserved.

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          Author and article information

          Journal
          23374865
          10.1016/j.bmcl.2012.12.102

          Chemistry
          Alkynes,chemistry,Azides,Bile Acids and Salts,chemical synthesis,Click Chemistry,Humans,Micelles,Molecular Conformation

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