Overview of the Korean Longitudinal Study on Cognitive Aging and Dementia

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Abstract

Objective

Due to an unprecedented rate of population aging, South Korea is facing a dementia epidemic. For this reason, the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) was launched in 2009 with support from the Korean Health Industry Development Institute to investigate the epidemiology, biopsychosocial risk factors, and outcomes of dementia and dementia-related conditions.

Methods

The KLOSCAD is the first nationwide multi-center population-based prospective cohort study. In October 2010, 12,694 individuals were randomly sampled from residents aged 60 years or older who lived in 13 districts across South Korea. In the baseline assessment, which was conducted from November 2010 through October 2012, 6,818 (53.7%) individuals participated. Follow-up assessments have been conducted every two years, with the first follow-up assessment conducted between November 2012 and October 2014, and the second between November 2014 and October 2016. The third is now in progress, and will span from November 2016 to October 2018. Diagnosis of cognitive disorders, neuropsychological battery, behavioral and psychological symptoms of dementia, activities of daily living, physical and neurologic examination and laboratory tests, life styles, quality of life, and identification of death were evaluated in each assessment.

Results

The cumulative drop-out rate at the second follow-up assessment was 38.7%. Dementia and mild cognitive impairment were 5.0% and 27.0%, respectively.

Conclusion

The KLOSCAD may provide strong scientific evidence for advancing the fight against dementia both in Korea and globally.

Related collections

Most cited references 33

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Author and article information

Journal

Journal ID (nlm-ta): Psychiatry Investig

Journal ID (iso-abbrev): Psychiatry Investig

Journal ID (publisher-id): PI

Title: Psychiatry Investigation

Publisher: Korean Neuropsychiatric Association

ISSN (Print): 1738-3684

ISSN (Electronic): 1976-3026

Publication date (Print): August 2018

Publication date (Electronic): 9 August 2018

Volume: 15

Issue: 8

Pages: 767-774

Affiliations

[1 ]Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea

[2 ]Department of Psychiatry, Yonsei University Wonju Severance Christian Hospital, Wonju, Republic of Korea

[3 ]Department of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju, Republic of Korea

[4 ]Department of Psychiatry, National Center for Mental Health, Seoul, Republic of Korea

[5 ]Department of Psychiatry, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

[6 ]Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea

[7 ]Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, Republic of Korea

[8 ]Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Chungju Hospital, Chungju, Republic of Korea

[9 ]Department of Neuropsychiatry, Jeju National University Hospital, Jeju, Republic of Korea

[10 ]Department of Neuropsychiatry, Changwon Gyeongsang National University Hospital, Changwon, Republic of Korea

[11 ]Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Medical Center, Seoul, Republic of Korea

[12 ]Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, Republic of Korea

[13 ]Department of Psychiatry, Bongseng Memorial Hospital, Busan, Republic of Korea

[14 ]Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea

[15 ]Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea

[16 ]Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea

[17 ]Department of Psychiatry, Dankook University Hospital, Cheonan, Republic of Korea

[18 ]Department of Psychiatry, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea

[19 ]Department of Psychiatry, Kangwon National University School of Medicine, Chuncheon, Republic of Korea

[20 ]Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, Republic of Korea

Author notes

Correspondence: Ki Woong Kim, MD, PhD Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, Republic of Korea, Department of Neuropsychiatry, Seoul National University College of Medicine and Seoul National University Bundang Hospital, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam 13620, Republic of Korea Tel: +82-31-787-7432, Fax: +82-31-787-4058, E-mail: kwkimmd@ 123456snu.ac.kr

Article

Publisher ID: pi-2018-06-02

DOI: 10.30773/pi.2018.06.02

PMC ID: 6111226

PubMed ID: 30086611

SO-VID: cda1d598-d3e1-4f20-9d1a-78ffaa7b2c63

License:

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

History

Date received : 1 May 2018

Date revision received : 18 May 2018

Date accepted : 2 June 2018

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Overview of the Korean Longitudinal Study on Cognitive Aging and Dementia

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Abstract

Objective

Methods

Results

Conclusion

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Karger: Neurology and Neuroscience

Most cited references 33

The MOS social support survey.

Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop.

A normative study of the CERAD neuropsychological assessment battery in the Korean elderly.

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Cited by 58

Most referenced authors 1,639