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      Hypersensitivity of Inner Medullary Collecting Duct Cells to Arginine Vasopressin and Forskolin in Cardiomyopathic Hamsters

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          Abstract

          Circulating arginine vasopressin (AVP) levels are elevated in congestive heart failure (CHF). However, the second messenger changes of the AVP system in CHF have not been explored. The aim of the present study is to determine whether there are changes in cAMP production in the AVP system in CHF. Cardiomyopathic hamsters of strain UM-X7.1 were used. Normal Golden Syrian hamsters were used as controls. IMCD cells were isolated from both group of hamsters. cAMP accumulation experiments were performed with AVP and forskolin stimulation in vitro. There was more cAMP release after stimulation by both AVP and forskolin in the cardiomyopathic than normal hamster IMCD cells. This illustrates that hypersensitivity of IMCD cells to AVP exists in cardiomyopathic hamsters. This may be partly explained by the presence of V2 receptor adenylate cyclase hyperactivity. The hypersensitivity of IMCD cells to AVP may be one of the factors causing fluid retention in CHF.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1993
          1993
          14 November 2008
          : 83
          : 1-2
          : 49-54
          Affiliations
          Department of Medicine, University of British Columbia, University Hospital, Vancouver, Canada
          Article
          175947 Cardiology 1993;83:49–54
          10.1159/000175947
          8261487
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          General Cardiology, Basic Research

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