10
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Respuesta terapéutica en enfermos con tuberculosis multidrogorresistente Translated title: Response to therapy in multiple drug resistant tuberculosis patients

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Introducción: la tuberculosis multidrogorresistente constituye un problema médico de gran importancia, porque implica la diseminación de microorganismos para los que es necesario aplicar medicamentos de la llamada "segunda línea", cuya efectividad es menor, requiere un tiempo de tratamiento más prolongado que aumenta la frecuencia de efectos indeseables, además de ser mucho más costoso que el tratamiento convencional. Objetivos: identificar la respuesta terapéutica al tratamiento individualizado en pacientes tuberculosos multidrogorresistentes no seropositivos al VIH. Métodos: se realizó un estudio descriptivo en una muestra de enfermos tuberculosos multidrogorresistentes tratados por al menos 1 año con esquemas individualizados, entre los años 2000 y 2010 en el Hospital Neumológico "Benéfico Jurídico". Se obtuvieron los datos de las historias clínicas individuales y las fichas bacteriológicas. Resultados: de los 42 pacientes, 85,7 % era de hombres y la edad media resultó 48,8 años. La categoría de caso más frecuente que motivó el ingreso fue la de crónico (40,5 %). El tiempo medio para el resultado negativo del examen directo fue de 4,6 meses y del cultivo 6 meses; resultó menor en los pacientes clasificados como fracasos y mayor en los clasificados como recaída. El mayor porcentaje de curación se obtuvo en los pacientes clasificados como crónicos y fracasos, con 23,8 y 21,4 %, respectivamente. Conclusiones: el cumplimiento del tratamiento individualizado directamente observado para tuberculosis multidrogorresistente resultó eficaz en más de la mitad de los casos.

          Translated abstract

          Introduction: multiple drug resistant tuberculosis is an increasingly significant medical problem, because it means the spread of microorganisms for which "second line" drugs are required to eliminate them; therapeutic effectiveness is lower, it takes longer to treat it, leading to more adverse effects in addition to being more expensive than the conventional treatment. Objective: to identify the response to individualized treatment in multiple drug resistant tuberculosis patients, who are non-HIV seropositive. Method: a descriptive study was conducted in a sample of multiple drug resistant patients, who were treated for a year under individualized courses of treatment from 2000 to 2010 in Hospital Neumológico "Benéfico Jurídico". Data were collected from their medical histories and from bacteriological records. Results: out of 42 patients, 85.7 % were males and the average age was 48.8 years. The most common category on admission was chronically-ill patient (40.5 %). The average time for negative results in direct exam was 4.6 months and in culturing was 6 months; this indicator was lower in patients regarded as failures and higher in those classified as relapses. The highest healing percentage was found in chronic patients and in those classified as failures, accounting for 23.8 and 21.4 % respectively. Conclusions: the compliance with individualized treatment under direct observation in multiple drug resistant tuberculosis proved to be effective in over half of the cases.

          Related collections

          Most cited references27

          • Record: found
          • Abstract: not found
          • Article: not found

          Anuario Estadístico de Salud

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Multidrug and extensively drug-resistant TB (M/XDR-TB): 2010 global report on surveillance and response

            (2010)
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The diagnosis of tuberculosis.

              Diagnostic testing for tuberculosis has remained unchanged for nearly a century, but newer technologies hold the promise of a true revolution in tuberculosis diagnostics. New tests may well supplant the tuberculin skin test in diagnosing latent tuberculosis infection in much of the world. Tests such as the nucleic acid amplification assays allow more rapid and accurate diagnosing of pulmonary and extrapulmonary tuberculosis. The appropriate and affordable use of any of these tests depends on the setting in which they are employed.
                Bookmark

                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                mtr
                Revista Cubana de Medicina Tropical
                Rev Cubana Med Trop
                Centro Nacional de Información de Ciencias Médicas (Ciudad de la Habana )
                1561-3054
                August 2012
                : 64
                : 2
                : 153-162
                Affiliations
                [1 ] Hospital Neumológico Benéfico Jurídico Cuba
                [2 ] Facultad de Medicina Dr. Salvador Allende Cuba
                Article
                S0375-07602012000200005
                cdaf5413-61b4-49aa-8fd0-7d0751be68b1

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Cuba

                Self URI (journal page): http://scielo.sld.cu/scielo.php?script=sci_serial&pid=0375-0760&lng=en
                Categories
                TROPICAL MEDICINE

                Infectious disease & Microbiology
                tuberculosis,multiple drug resistance,response to therapy,multidrogorresistencia,respuesta terapeútica

                Comments

                Comment on this article