Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trials.

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Abstract

The peripheral blood eosinophil count might help identify those patients with chronic obstructive pulmonary disease (COPD) who will experience fewer exacerbations when taking inhaled corticosteroids (ICS). Previous post-hoc analyses have proposed eosinophil cutoffs that are both arbitrary and limited in evaluating complex interactions of treatment response. We modelled eosinophil count as a continuous variable to determine the characteristics that determine both exacerbation risk and clinical response to ICS in patients with COPD.

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Journal

Journal ID (iso-abbrev): Lancet Respir Med

Title: The Lancet. Respiratory medicine

Publisher: Elsevier BV

ISSN (Electronic): 2213-2619

ISSN (Print): 2213-2600

Publication date (Electronic): February 2018

Volume: 6

Issue: 2

Affiliations

[1 ] Respiratory Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. Electronic address: mona.bafadhel@ndm.ox.ac.uk.

[2 ] StatMind, Lund, Sweden.

[3 ] Global Medical Affairs, AstraZeneca, Cambridge, UK.

[4 ] School of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

[5 ] Early Clinical Development, IMED Biotech Unit, AstraZeneca, Cambridge, UK; Department of Internal Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of Nebraska Medical Center, Omaha, NE, USA.

[6 ] Global Medical Affairs, AstraZeneca, Molndal, Sweden; Country Medical Director, AstraZeneca, Wedel, Germany.

[7 ] Global Medical Affairs, AstraZeneca, Molndal, Sweden.

Article

Publisher Item ID: S2213-2600(18)30006-7

DOI: 10.1016/S2213-2600(18)30006-7

PubMed ID: 29331313

SO-VID: cdd3867b-35ba-4107-99c9-e65480ae859b

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