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      Cognitive impairment in multiple sclerosis

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      The Lancet Neurology
      Elsevier BV

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          Abstract

          Multiple sclerosis (MS) is a progressive disease of the CNS that is characterised by widespread lesions in the brain and spinal cord. MS results in motor, cognitive, and neuropsychiatric symptoms, all of which can occur independently of one another. The common cognitive symptoms include deficits in complex attention, efficiency of information processing, executive functioning, processing speed, and long-term memory. These deficits detrimentally affect many aspects of daily life, such as the ability to run a household, participate fully in society, and maintain employment--factors that can all affect the overall quality of life of the patient. The increased use of neuroimaging techniques in patients with MS has advanced our understanding of structural and functional changes in the brain that are characteristic of this disease, although much remains to be learned. Moreover, examination of efforts to treat the cognitive deficits in MS is still in the early stages.

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          Author and article information

          Journal
          The Lancet Neurology
          The Lancet Neurology
          Elsevier BV
          14744422
          December 2008
          December 2008
          : 7
          : 12
          : 1139-1151
          Article
          10.1016/S1474-4422(08)70259-X
          19007738
          cddbe8f3-4033-49e1-8dba-d93874ee0472
          © 2008

          https://www.elsevier.com/tdm/userlicense/1.0/


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