Multiple sclerosis (MS) is a progressive disease of the CNS that is characterised
by widespread lesions in the brain and spinal cord. MS results in motor, cognitive,
and neuropsychiatric symptoms, all of which can occur independently of one another.
The common cognitive symptoms include deficits in complex attention, efficiency of
information processing, executive functioning, processing speed, and long-term memory.
These deficits detrimentally affect many aspects of daily life, such as the ability
to run a household, participate fully in society, and maintain employment--factors
that can all affect the overall quality of life of the patient. The increased use
of neuroimaging techniques in patients with MS has advanced our understanding of structural
and functional changes in the brain that are characteristic of this disease, although
much remains to be learned. Moreover, examination of efforts to treat the cognitive
deficits in MS is still in the early stages.