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      Categorization of the main descriptors of different ampicillin crystal habits

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          Abstract

          With the purpose of enabling the analysis by digital methods of particles of multisource pharmaceutical raw materials, this study analyzed different crystal habits of ampicillin particles, by grouping the external shapes obtained from 3 different solvents (acetonitrile, ethanol, and methanol), thereby reducing the number of descriptors necessary to adequately represent each shape. For this purpose, a selection of morphological descriptors was used including: circularity, roughness, roundness, compactness, aspect ratio, effective diameter, solidity, convexity, fractal dimension, and 10 Complex Fourier descriptors. These measures cover highly diverse morphological properties and define the crystal habit of a particle. Principal Component Analysis (PCA) and the Cluster Analysis (CA) were the grouping techniques used, which demonstrated the possibility of using between 2 and 4 descriptors instead of the 18 proposed initially.

          Translated abstract

          Com o objetivo de possibilitar a análise, por meio de métodos digitais, de partículas de matérias-primas farmacêuticas de múltiplas fontes, analisaram-se diferentes cristais de partículas de ampicilina através do agrupamento de formas externas obtidas de três diferentes solventes (acetonitrila, etanol e metanol), reduzindo, desse modo, o número de descritores necessários para representar adequadamente cada forma. Com esse propósito, utilizou-se seleção de descritores morfológicos, incluindo: circularidade, aspereza, arredondamento, compactação, relação de aspecto, diâmetro efetivo, solidez, convectividade, dimensão fractal e 10 descritores complexos de Fourier. Essas medidas cobrem diversas propriedades morfológicas e definem a cristalinidade de uma partícula. As análises do componente principal (PCA) e por grupamento (CA) foram as técnicas de agrupamento utilizadas, que demonstraram a possibilidade de utilizar entre 2 e 4 descritores ao invés dos 18, inicialmente propostos.

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          Most cited references22

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          A New Roundness Scale for Sedimentary Particles

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            Characterization of habits and crystalline modification of solids and their pharmaceutical applications.

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              • Article: not found

              Quantitative shape analysis: A review

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                Author and article information

                Journal
                bjps
                Brazilian Journal of Pharmaceutical Sciences
                Braz. J. Pharm. Sci.
                Universidade de São Paulo, Faculdade de Ciências Farmacêuticas (São Paulo, SP, Brazil )
                2175-9790
                December 2010
                : 46
                : 4
                : 679-685
                Affiliations
                [01] orgnameUniversity of Antioquia orgdiv1Faculty of Pharmaceutical Chemistry orgdiv2Department of Pharmacy
                [02] orgnameUniversity of Antioquia orgdiv1Faculty of Engineering orgdiv2Department of Electric Engineering
                Article
                S1984-82502010000400009 S1984-8250(10)04600409
                10.1590/S1984-82502010000400009
                cddc254d-4c4c-4cec-b1aa-0a23b718fa85

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 19 May 2010
                : 04 May 2009
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 23, Pages: 7
                Product

                SciELO Brazil

                Categories
                Articles

                Descritores Fourier,Morphological descriptors,Multisource solids,Análise multivariada,Cristal,Descritores morfológicos,Sólidos de múltiplas fontes,Multivariate analysis,Crystal habits,Fourier descriptors

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