For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
11
views
28
references
 Top references
cited by
8
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      156
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Functionalized β-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Cyclodextrins (CDs) have beneficial characteristics for drug delivery, including hydrophobic interior surfaces. Nanocarriers with β-CD ligands have been prepared with simple surface modifications as drug delivery vehicles. In this study, we synthesized β-CD derivatives on an Ag-embedded silica nanoparticle (NP) (SiO 2@Ag NP) structure to load and release doxorubicin (DOX). Cysteinyl- β-CD and ethylenediamine- β-CD (EDA- β-CD) were immobilized on the surface of SiO 2@Ag NPs, as confirmed by transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FTIR) spectroscopy. DOX was introduced into the β-CD on the SiO 2@Ag NPs and then successfully released. Neither cysteinyl- β-CD and EDA- β-CD showed cytotoxicity, while DOX-loaded cysteinyl- β-CD and EDA- β-CD showed a significant decrease in cell viability in cancer cells. The SiO 2@Ag NPs with β-CD provide a strategy for designing a nanocarrier that can deliver a drug with controlled release from modified chemical types.

          Related collections

          Most cited references28

          • Record: found
          • Abstract: not found
          • Article: not found

          Cyclodextrins and their uses: a review

          E.M.Martin Del Valle (2004)
          Article 0 comments Cited 488 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Cyclodextrin-based polymeric materials: synthesis, properties, and pharmaceutical/biomedical applications.

            Wim E Hennink, Frank N. Van Leeuwen, Tina Vermonden (2009)
            This review describes the synthesis, properties, and, in particular, biomedical and pharmaceutical applications of an upcoming class of polymeric networks and assemblies based on cyclodextrins (CDs). CDs are cyclic oligosaccharides composed of alpha-1,4-coupled d-glucose units, which contain a hydrophobic internal cavity that can act as a host for various, generally lipophilic, guest molecules. Because of this unique physicochemical property, commonly referred to as inclusion complex formation, CDs have often been used to design polymeric materials, such as hydrogels and nanoparticles. Polymeric systems based on CDs exhibit unique characteristics in terms of mechanical properties, stimuli-responsiveness, and drug release characteristics. In this contribution, first, an outline is given of covalently cross-linked polymeric networks in which CD moieties were structurally incorporated to modulate the network strength as well as the complexation and release of low molecular weight drugs. Second, physically assembled polymeric systems are discussed, of which the formation is accomplished by inclusion complexes between polymer-conjugated CDs and various guest molecule-derivatized polymers. Due to their physical nature, these polymeric systems are sensitive to external stimuli, such as temperature changes, shear forces and the presence of competing CD-binding molecules, which can be exploited to use these systems as injectable, in situ gelling devices. In recent years, many interesting CD-containing polymeric systems have been described in literature. These systems have to be optimized and extensively evaluated in preclinical studies concerning their safety and efficacy, making future clinical applications of these materials in the biomedical and pharmaceutical field feasible.
            Article 0 comments Cited 121 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Synthesis and surface functionalization of silica nanoparticles for nanomedicine.

              Alexander S Liberman (2014)
              There are a wide variety of silica nanoformulations being investigated for biomedical applications. Silica nanoparticles can be produced using a wide variety of synthetic techniques with precise control over their physical and chemical characteristics. Inorganic nanoformulations are often criticized or neglected for their poor tolerance; however, extensive studies into silica nanoparticle biodistributions and toxicology have shown that silica nanoparticles may be well tolerated, and in some case are excreted or are biodegradable. Robust synthetic techniques have allowed silica nanoparticles to be developed for applications such as biomedical imaging contrast agents, ablative therapy sensitizers, and drug delivery vehicles. This review explores the synthetic techniques used to create and modify an assortment of silica nanoformulations, as well as several of the diagnostic and therapeutic applications.
              Article 0 comments Cited 85 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Int J Mol Sci
                Journal ID (iso-abbrev): Int J Mol Sci
                Journal ID (publisher-id): ijms
                Title: International Journal of Molecular Sciences
                Publisher: MDPI
                ISSN (Electronic): 1422-0067
                Publication date (Electronic): 14 January 2019
                Publication date Collection: January 2019
                Volume: 20
                Issue: 2
                Electronic Location Identifier: 315
                Affiliations
                [1 ]Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea; ejkang@ 123456konkuk.ac.kr (E.J.K.); undine1213@ 123456naver.com (Y.M.B.); greenice@ 123456konkuk.ac.kr (E.H.); shlee.ucb@ 123456gmail.com (S.H.L.); phamricky@ 123456gmail.com (X.-H.P.); kimde@ 123456konkuk.ac.kr (D.-E.K.)
                [2 ]Bio-Health Convergence Institute, Korea Testing Certification, Gunpo 15809, Korea; pourlady@ 123456ktc.re.kr
                Author notes
                [* ]Correspondence: bjun@ 123456konkuk.ac.kr ; Tel.: +82-450-0521
                Author information
                https://orcid.org/0000-0002-4927-7102
                https://orcid.org/0000-0001-6556-7946
                Article
                Publisher ID: ijms-20-00315
                DOI: 10.3390/ijms20020315
                PMC ID: 6359520
                PubMed ID: 30646562
                SO-VID: cde0f952-0ea3-4de1-9bf8-bda362ce86bc
                Copyright © © 2019 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 18 December 2018
                Date accepted : 12 January 2019
                Categories
                Subject: Article

                ScienceOpen disciplines: Molecular biology
                Keywords: cyclodextrin,doxorubicin (dox),drug delivery
                Data availability:
                ScienceOpen disciplines: Molecular biology
                Keywords: cyclodextrin, doxorubicin (dox), drug delivery

                Comments

                Comment on this article

                scite_

                Similar content156

                See all similar

                Cited by8

                See all cited by

                Most referenced authors753

                See all reference authors