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      Copper, Lead, Cadmium and Calcium in Cataractous Lenses

      Ophthalmic Research
      S. Karger AG
      Cataract, Copper, Lead, Cadmium, Calcium

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          Lenticular copper, lead, cadmium and calcium levels were measured using atomic absorption spectrophotometry in 9 normal and 37 cataractous human lenses. The nuclear parts of the lenses were used for the study in both groups. The lenticular deposition of these four elements in cataract was statistically significant. In the cataractous group, males had higher levels of cadmium compared to females. No lead was detected in normal lenses. The calcium content was significantly higher in cortical cataract whereas the other elements were not correlated with the types of cataract.

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          Most cited references1

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          Mechanisms of lead and cadmium nephrotoxicity.

          R.A. Goyer (1989)
          Exposure to lead results in accumulation in proximal renal tubular lining cells in the form of morphologically discernible inclusion bodies which are lead-protein complexes. Acute nephrotoxicity consists of proximal tubular dysfunction and can be reversed by treatment with chelating agents. Chronic lead nephrotoxicity consists of interstitial fibrosis and progressive nephron loss, azotaemia and renal failure. Potential complications of lead nephropathy include gout and hypertension. Cadmium accumulates in renal tubular lining cells bound to metallothionein, a small protein containing 30% cystine. Metallothionein protects against nephrotoxicity by binding cadmium in a nontoxic form. Renal tubular dysfunction and chronic interstitial fibrosis occur when cadmium levels in the renal cortex exceed the critical concentration of about 200 micrograms/g. Recommendations are made for specific research needs.

            Author and article information

            Ophthalmic Res
            Ophthalmic Research
            S. Karger AG
            February 1998
            15 January 1998
            : 30
            : 1
            : 49-53
            SSK Ankara Eye Hospital, Ankara, Turkey
            55454 Ophthalmic Res 1998;30:49–53
            © 1998 S. Karger AG, Basel

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            Page count
            Tables: 4, References: 20, Pages: 5
            Original Paper

            Vision sciences,Ophthalmology & Optometry,Pathology
            Vision sciences, Ophthalmology & Optometry, Pathology
            Calcium, Copper, Cataract, Lead, Cadmium


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