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      • Record: found
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      Copper, Lead, Cadmium and Calcium in Cataractous Lenses

      research-article
      Ophthalmic Research
      S. Karger AG
      Cataract, Copper, Lead, Cadmium, Calcium

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          Abstract

          Lenticular copper, lead, cadmium and calcium levels were measured using atomic absorption spectrophotometry in 9 normal and 37 cataractous human lenses. The nuclear parts of the lenses were used for the study in both groups. The lenticular deposition of these four elements in cataract was statistically significant. In the cataractous group, males had higher levels of cadmium compared to females. No lead was detected in normal lenses. The calcium content was significantly higher in cortical cataract whereas the other elements were not correlated with the types of cataract.

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          Most cited references1

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          Mechanisms of lead and cadmium nephrotoxicity.

          R.A. Goyer (1989)
          Exposure to lead results in accumulation in proximal renal tubular lining cells in the form of morphologically discernible inclusion bodies which are lead-protein complexes. Acute nephrotoxicity consists of proximal tubular dysfunction and can be reversed by treatment with chelating agents. Chronic lead nephrotoxicity consists of interstitial fibrosis and progressive nephron loss, azotaemia and renal failure. Potential complications of lead nephropathy include gout and hypertension. Cadmium accumulates in renal tubular lining cells bound to metallothionein, a small protein containing 30% cystine. Metallothionein protects against nephrotoxicity by binding cadmium in a nontoxic form. Renal tubular dysfunction and chronic interstitial fibrosis occur when cadmium levels in the renal cortex exceed the critical concentration of about 200 micrograms/g. Recommendations are made for specific research needs.
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            Author and article information

            Journal
            ORE
            Ophthalmic Res
            10.1159/issn.0030-3747
            Ophthalmic Research
            S. Karger AG
            0030-3747
            1423-0259
            1998
            February 1998
            15 January 1998
            : 30
            : 1
            : 49-53
            Affiliations
            SSK Ankara Eye Hospital, Ankara, Turkey
            Article
            55454 Ophthalmic Res 1998;30:49–53
            10.1159/000055454
            9483588
            cdf37cf3-b31c-4c0c-a0c8-c44dead85886
            © 1998 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            History
            Page count
            Tables: 4, References: 20, Pages: 5
            Categories
            Original Paper

            Vision sciences,Ophthalmology & Optometry,Pathology
            Calcium,Copper,Cataract,Lead,Cadmium
            Vision sciences, Ophthalmology & Optometry, Pathology
            Calcium, Copper, Cataract, Lead, Cadmium

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