The Emperor’s New Clothes: Prospective Observational Evaluation of the Association between Initial Vancomycin Exposure and Failure Rates among Adult Hospitalized Patients with MRSA Bloodstream Infections (PROVIDE)

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Abstract

Vancomycin is the most commonly administered antibiotic in hospitalized patients, but optimal exposure targets remain controversial. To clarify the therapeutic exposure range, this study evaluated the association between vancomycin exposure and outcomes in patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia.

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Journal

Title: Clinical Infectious Diseases

Publisher: Oxford University Press (OUP)

ISSN (Print): 1058-4838

ISSN (Electronic): 1537-6591

Publication date Created: June 03 2019

Publication date (Electronic): June 03 2019

Affiliations

[1 ]Albany College of Pharmacy and Health Sciences, Albany, NY

[2 ]Harvard T.H. Chan School of Public Health, Boston, MA

[3 ]Department of Epidemiology and Biostatistics, Biostatistics Center, George Washington University, Washington, DC

[4 ]William Beaumont Hospital, Royal Oak, MI

[5 ]Henry Ford Health System, Detroit, MI

[6 ]Vanderbilt University Medical Center, Nashville, TN

[7 ]University of Rochester Medical Center, Rochester, NY

[8 ]Montefiore Medical Center, Bronx, NY

[9 ]University of Pittsburgh, Pittsburgh, PA

[10 ]Midwestern University Chicago College of Pharmacy, Department of Pharmacy Practice, Chicago College of Osteopathic Medicine, Department of Pharmacology, Downers Grove, IL

[11 ]Northwestern Memorial Hospital, Chicago, IL

[12 ]University of Alabama Birmingham Department of Medicine, Birmingham, AL

[13 ]Greenville Hospital System University Medical Center, Greenville, SC

[14 ]University of Illinois Hospital and Health Sciences System, Chicago, IL

[15 ]Division of Infectious Diseases and HIV Medicine, Drexel University College of Medicine, Philadelphia, PA

[16 ]University of Colorado Denver, Aurora, CO

[17 ]University of Washington Medical Center, Seattle, WA

[18 ]Medical University of South Carolina, Charleston, SC

[19 ]San Francisco General Hospital, San Francisco, CA

[20 ]Duke Clinical Research Institute, Durham, NC

[21 ]Duke University Medical Center, Durham, NC

Article

DOI: 10.1093/cid/ciz460

PMC ID: 7145993

PubMed ID: 31157370

SO-VID: cdfec801-3d41-451f-ae91-601e60d95859

License:

https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model

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