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      Effects of Kudoa septempunctata genotype ST3 isolate from Korea on ddY suckling mice Translated title: Effets de Kudoa septempunctata, génotype ST3 isolé de Corée, sur des souriceaux ddY à la mamelle

      1 , * , 2 , 3 , 1

      Parasite

      EDP Sciences

      Kudoa septempunctata, ST3 genotype, Food-borne disease, Myxozoa, Paralichthys olivaceus, suckling mice

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          Abstract

          This study investigated the effects of Kudoa septempunctata genotype ST3 spores on ddY suckling mice. Purified Kudoa septempunctata spores were administered into the stomachs of the mice at 5 × 10 6 or 5 × 10 7 spores/mouse, with inactivated Kudoa (5 × 10 6 spores/mouse) or vehicle as controls. No abnormal clinical symptoms were observed and there were no variations in fluid accumulation ratio and cytokine gene expression in all groups. In addition, intact Kudoa spores and the 18S rDNA gene were only detected (by microscopy and quantitative PCR, respectively) in the groups administered such spores. This study thus confirms that spores from the ST3 strain of Kudoa septempunctata were excreted in the faeces without infecting the gastrointestinal tract in ddY suckling mice.

          Translated abstract

          Cette étude a examiné les effets des spores de Kudoa septempunctata, de génotype ST3, sur des souriceaux à la mamelle de race ddY. Les spores purifiées de Kudoa septempunctata ont été administrées dans les estomacs des souris à 5 × 10 6 ou 5 × 10 7 spores/souris, avec comme témoins des Kudoa inactivés (5 × 10 6 spores/souris) ou un véhicule. Dans tous les groupes, aucun symptôme clinique anormal n’a été observé et il n’y avait pas de variation dans les taux d’accumulation de fluide ni dans l’expression des gènes de cytokines. De plus, des spores de Kudoa intactes et le gène d’ADNr 18S de Kudoa ont été détectés uniquement (par microscopie et PCR quantitative, respectivement) dans les groupes auxquels ont été administrées ces spores. Cette étude confirme donc que les spores de la souche ST3 de Kudoa septempunctata ont été excrétées dans les fèces sans infecter le tractus gastro-intestinal chez les souriceaux ddY à la mamelle.

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          Most cited references 8

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          Mouse strain-dependent differences in susceptibility to Neisseria gonorrhoeae infection and induction of innate immune responses.

          Acute gonorrhea in women is characterized by a mucopurulent exudate that contains polymorphonuclear leukocytes (PMNs) with intracellular gonococci. Asymptomatic infections are also common. Information on the innate response to Neisseria gonorrhoeae in women is limited to studies with cultured cells, isolated immune cells, and analyses of cervicovaginal fluids. 17beta-Estradiol-treated BALB/c mice can be experimentally infected with N. gonorrhoeae, and a vaginal PMN influx occurs in 50 to 80% of mice. Here, we compared the colonization loads and proinflammatory responses of BALB/c, C57BL/6 and C3H/HeN mice to N. gonorrhoeae. BALB/c and C57BL/6 mice were colonized at similar levels following inoculation with 10(6) CFU of N. gonorrhoeae. BALB/c, but not C57BL/6, mice exhibited a marked vaginal PMN influx. Tumor necrosis factor alpha, interleukin-6, macrophage inflammatory protein 2 (MIP-2), and keratinocyte-derived chemokine were elevated in vaginal secretions from infected BALB/c mice, but not in those from C57BL/6 mice. MIP-2 levels positively correlated with a vaginal PMN influx. In contrast to BALB/c and C57BL/6 mice, C3H/HeN mice were resistant to infection, and there was no evidence of an inflammatory response. We conclude that N. gonorrhoeae causes a productive infection in BALB/c mice that is characterized by the induction of proinflammatory cytokines and chemokines and the recruitment of PMNs. Infection of C57BL/6 mice, in contrast, is more similar to asymptomatic infection. C3H/HeN mice are inherently resistant to N. gonorrhoeae infection, and this resistance is not due to an overwhelming inflammatory response to infection. Host genetic factors can therefore impact susceptibility and the immune response to N. gonorrhoeae.
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            Synopsis of the species of Kudoa Meglitsch, 1947 (Myxozoa: Myxosporea: Multivalvulida).

            A synopsis of the species of Kudoa Meglitsch, 1947 (Myxozoa, Myxosporea, Multivalvulida) is presented, including 95 nominal species. For each species the most relevant morphological and morphometric features are indicated in tabulated format. Included are data on the site of infection within the host, the type-host and type-locality, plus a full bibliography of the original records for these species. Molecular data (GenBank accession numbers) are also provided whenever possible.
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              The involvement of TNF, IL-1 and IL-6 in the immune response to protozoan parasites.

              One early reaction of the host to infection with protozoan parasites is the secretion of an array of potent cytokines including tumor necrosis factor (TNF), interleukin (IL-1) and IL-6. The combined action of these cytokines causes fever, leukocytosis and the production of acute phase proteins such as C-reactive protein (CRP). These early responses contribute significantly to the outcome of infection by influencing the course of infection directly and by regulating the specific immune response to the parasite.
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                Author and article information

                Journal
                Parasite
                Parasite
                parasite
                Parasite
                EDP Sciences
                1252-607X
                1776-1042
                2016
                11 April 2016
                : 23
                : ( publisher-idID: parasite/2016/01 )
                Affiliations
                [1 ] Ocean and Fisheries Research Institute, Jeju Special Self-Governing Province Pyoseon-myeon, Segwipo-si Jeju 63629 Republic of Korea
                [2 ] School of Medicine, Jeju National University Jeju 63243 Republic of Korea
                [3 ] College of Veterinary Medicine, Jeju National University Jeju 63243 Republic of Korea
                Author notes
                [* ]Corresponding author: jyh4586@ 123456korea.kr
                Article
                parasite160015 10.1051/parasite/2016020
                10.1051/parasite/2016020
                4828580
                27067108
                © Y. Jang et al., published by EDP Sciences, 2016

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                Page count
                Figures: 6, Tables: 1, Equations: 0, References: 20, Pages: 7
                Categories
                Research Article

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