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Gluteofemoral body fat as a determinant of metabolic health

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International Journal of Obesity

Springer Science and Business Media LLC

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      Positional cloning of the mouse obese gene and its human homologue.

      The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese (ob) gene. Mutation of ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.
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        Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.

        We isolated the human adipose-specific and most abundant gene transcript, apM1 (Maeda, K., et al., Biochem. Biophys. Res. Commun. 221, 286-289, 1996). The apM1 gene product was a kind of soluble matrix protein, which we named adiponectin. To quantitate the plasma adiponectin concentration, we have produced monoclonal and polyclonal antibodies for human adiponectin and developed an enzyme-linked immunosorbent assay (ELISA) system. Adiponectin was abundantly present in the plasma of healthy volunteers in the range from 1.9 to 17.0 mg/ml. Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adiponectin is secreted only from adipose tissue. The ELISA system developed in this study will be useful for elucidating the physiological and pathophysiological role of adiponectin in humans. Copyright 1999 Academic Press.
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          Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

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            Author and article information

            Journal
            International Journal of Obesity
            Int J Obes
            Springer Science and Business Media LLC
            0307-0565
            1476-5497
            June 2010
            January 12 2010
            June 2010
            : 34
            : 6
            : 949-959
            10.1038/ijo.2009.286
            © 2010

            http://www.springer.com/tdm

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