For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
8
views
47
references
 Top references
cited by
11
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      710
      similar
       All similar
      • Record: found
      • Abstract: not found
      • Article: not found

      Differentiation and histogenesis of syringomatous tumour of the nipple and low-grade adenosquamous carcinoma: evidence for a common origin

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Syringomatous tumour of the nipple and low-grade adenosquamous carcinoma (LGAdSC) of the breast are regarded as distinct entities. To clarify the nature of these two lesions, we compared the expression of different lineage/differentiation markers in 12 syringomatous tumours of the nipple, nine LGAdSCs, and normal breast epithelium.

          Related collections

          Most cited references47

          • Record: found
          • Abstract: not found
          • Article: not found

          The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells.

          Roland Moll, Werner W. Franke, Dorothea L. Schiller … (1982)
          Article 0 comments Cited 466 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            p63 Is essential for the proliferative potential of stem cells in stratified epithelia.

            Makoto Senoo, Filipa C.S.C. Pinto, Christopher Crum … (2007)
            The distinguishing feature of adult stem cells is their extraordinary capacity to divide prior to the onset of senescence. While stratified epithelia such as skin, prostate, and breast are highly regenerative and account disproportionately for human cancers, genes essential for the proliferative capacity of their stem cells remain unknown. Here we analyze p63, a gene whose deletion in mice results in the catastrophic loss of all stratified epithelia. We demonstrate that p63 is strongly expressed in epithelial cells with high clonogenic and proliferative capacity and that stem cells lacking p63 undergo a premature proliferative rundown. Additionally, we show that p63 is dispensable for both the commitment and differentiation of these stem cells during tissue morphogenesis. Together, these data identify p63 as a key, lineage-specific determinant of the proliferative capacity in stem cells of stratified epithelia.
            Article 0 comments Cited 263 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              p63 is a prostate basal cell marker and is required for prostate development.

              Rebecca Dilks, F McKeon, D Waltregny … (2000)
              The p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives (DeltaNp63). p63 is expressed in the basal cells of many epithelial organs and its germline inactivation in the mouse results in agenesis of organs such as skin appendages and the breast. Here, we show that prostate basal cells, but not secretory or neuroendocrine cells, express p63. In addition, prostate basal cells in culture predominantly express the DeltaNp63alpha isotype. In contrast, p63 protein is not detected in human prostate adenocarcinomas. Finally, and most importantly, p63(-/-) mice do not develop the prostate. These results indicate that p63 is required for prostate development and support the hypothesis that basal cells represent and/or include prostate stem cells. Furthermore, our results show that p63 immunohistochemistry may be a valuable tool in the differential diagnosis of benign versus malignant prostatic lesions.
              Article 0 comments Cited 102 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Title: Histopathology
                Abbreviated Title: Histopathology
                Publisher: Wiley
                ISSN: 03090167
                Publication date Created: July 2014
                Publication date (Print): July 2014
                Publication date (Electronic): April 09 2014
                Volume: 65
                Issue: 1
                Pages: 9-23
                Affiliations
                [1 ]Institute for Hematopathology; Reference Centre for Gynaeco- and Breast Pathology; Hamburg Germany
                [2 ]Gerhard-Domagk-Institute of Pathology; University of Muenster; Münster Germany
                [3 ]Sahlgrenska Cancer Centre; Department of Pathology; University of Gothenburg; Gothenburg Sweden
                [4 ]Albertinen Pathology; Hamburg Germany
                [5 ]Institute of Pathology; University Clinic; Heidelberg Germany
                [6 ]Institute of Pathology; University of Lübeck; Lübeck Germany
                [7 ]Department of Pathology; Clinical Hospital Centre Sestre Milosrdnice; Zagreb Croatia
                Article
                DOI: 10.1111/his.12358
                PubMed ID: 24382117
                SO-VID: ce1e17b3-1b11-4353-9e6f-268cd7bc6c65
                Copyright © © 2014
                License:

                http://doi.wiley.com/10.1002/tdm_license_1.1

                History

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content710

                See all similar

                Cited by11

                See all cited by

                Most referenced authors550

                See all reference authors