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      Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.

      Science (New York, N.Y.)
      Aged, Aged, 80 and over, Aging, Alleles, Alzheimer Disease, genetics, metabolism, mortality, Amyloid beta-Peptides, Apolipoprotein E4, Apolipoproteins E, physiology, Female, Gene Frequency, Genotype, Homozygote, Humans, Linkage Disequilibrium, Male, Risk Factors, Survival Rate

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          The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.

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