Mineral trioxide aggregate (MTA) has been recommended for various uses in endodontics.
Two previous publications provided a comprehensive list of articles from November
1993-September 2009 regarding the chemical and physical properties, sealing ability,
antibacterial activity, leakage, and biocompatibility of MTA. The purpose of Part
III of this literature review is to present a comprehensive list of articles regarding
animal studies, clinical applications, drawbacks, and mechanism of action of MTA.
A review of the literature was performed by using electronic and hand-searching methods
for the clinical applications of MTA in experimental animals and humans as well as
its drawbacks and mechanism of action from November 1993-September 2009.
MTA is a promising material for root-end filling, perforation repair, vital pulp therapy,
and apical barrier formation for teeth with necrotic pulps and open apexes. Despite
the presence of numerous case reports and case series regarding these applications,
there are few designed research studies regarding clinical applications of this material.
MTA has some known drawbacks such as a long setting time, high cost, and potential
of discoloration. Hydroxyapatite crystals form over MTA when it comes in contact with
tissue synthetic fluid. This can act as a nidus for the formation of calcified structures
after the use of this material in endodontic treatments.
On the basis of available information, it appears that MTA is the material of choice
for some clinical applications. More clinical studies are needed to confirm its efficacy
compared with other materials.
Copyright (c) 2010. Published by Elsevier Inc.