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      Effect of Vertebral Artery Infusions of Oxytocin on Plasma Vasopressin Concentration, Plasma Renin Activity, Blood Pressure and Heart Rate and Their Responses to Hemorrhage

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          Infusion of oxytocin into one vertebral artery of anesthetized dogs did not alter plasma vasopressin concentration, blood pressure or heart rate. However, there was a significant (p < 0.01) increase in plasma renin activity (PRA; Δ = 7.6 ± 2.3 ng/ml · h). A 35% hemorrhage caused blood pressure to fall by 9.4 ± 4.0 mmHg (p < 0.01) and PRA to rise by 8.8 ± 2.7 ng/ml · h (p < 0.05). In 8 dogs that were subjected to a similar hemorrhage and that also received an intravertebral infusion of oxytocin, blood pressure was maintained and PRA increased by 14 + 4.3 ng/ml · h (p < 0.05). Heart rate and plasma vasopressin responses were similar in both hemorrhage groups. The results indicate that oxytocin prevented the fall in blood pressure associated with a hemorrhage, possibly by increasing renin release.

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          Author and article information

          S. Karger AG
          28 March 2008
          : 38
          : 5
          : 382-386
          Department of Physiology and Biophysics, University of Tennessee Center for the Health Sciences, Memphis, Tenn., USA
          123921 Neuroendocrinology 1984;38:382–386
          © 1984 S. Karger AG, Basel

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          Pages: 5
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