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      Porphyrin Containing Polymersomes with Enhanced ROS Generation Efficiency: In Vitro Evaluation.

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          Abstract

          Porphyrins are molecules possessing unique photophysical properties making them suitable for application in photodynamic therapy. The incorporation of porphyrins into natural or synthetic nano-assemblies such as polymersomes is a strategy to improve and prolong their therapeutic capacities and to overcome their limitations as therapeutic and diagnostic agents. Here, 5,10,15,20-tetrakis(1-(6-ethoxy-6-oxohexyl)-4-pyridin-1-io)-21H,23H-porphyrin tetrabromide porphyrin is inserted into polymersomes in order to demonstrate that the encapsulation enhances its ability to generate highly reactive singlet oxygen (1 O2 ) upon irradiation in vitro. The photoactivation of the free and polymersome-encapsulated porphyrin is evaluated by electron spin resonance and cell viability assays on three different mammalian cell lines. The results indicate that by encapsulating the porphyrin, a controlled ROS delivery within the cells is achieved, at the same time avoiding side effects such as dark toxicity, non-specific porphyrin release and over time decreased activity in vitro. This work focuses on showing a not-toxic model system for modern therapeutic nanomedicine, which works under mild irradiation and dosage conditions.

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          Author and article information

          Journal
          Macromol Biosci
          Macromolecular bioscience
          Wiley
          1616-5195
          1616-5187
          Feb 2020
          : 20
          : 2
          Affiliations
          [1 ] Department of Chemistry, University of Basel, Mattenstrasse 24a 4058 Basel, Switzerland.
          Article
          10.1002/mabi.201900291
          31825559
          ce56ec82-3e22-447d-b96c-cafff7fe6be6
          History

          porphyrin,polymersomes,photoactivation,nanocarrier,reactive oxygen species delivery

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