EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition.

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Abstract

Epithelial-mesenchymal transition (EMT) is a cellular process involved in cancer progression. The first step of EMT consists in the disruption of E-cadherin-mediated adherens junctions. Cholangiocarcinoma (CCA), a cancer with a poor prognosis due to local invasion and metastasis, displays EMT features. EGFR, a receptor tyrosine kinase, plays a major role in CCA progression. The aim of the study was to determine if EMT is induced by EGFR in CCA cells.

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Journal

Journal ID (iso-abbrev): J. Hepatol.

Title: Journal of hepatology

ISSN (Electronic): 1600-0641

ISSN (Print): 0168-8278

Publication date (Electronic): Aug 2014

Volume: 61

Issue: 2

Affiliations

[1 ] INSERM, UMR_S 938, Centre de Recherche Saint-Antoine, F-75012 Paris, France; UPMC, Univ Paris 06, UMR_S 938, Centre de Recherche Saint-Antoine, F-75012 Paris, France.

[2 ] CNRS UMR 144, Institut Curie, F-75005 Paris, France.

[3 ] INSERM, UMR_S 938, Centre de Recherche Saint-Antoine, F-75012 Paris, France; UPMC, Univ Paris 06, UMR_S 938, Centre de Recherche Saint-Antoine, F-75012 Paris, France; AP-HP, Hôpital Saint-Antoine, Service d'Anatomie et Cytologie Pathologiques, F-75012 Paris, France.

[4 ] INSERM, UMR_S938, Centre de Recherche Saint-Antoine, Plateforme Morphologie du Petit Animal, F-75012 Paris, France.

[5 ] INSERM, UMRS_U773 & AP-HP, Hôpital Beaujon, Service de Pathologie, F-92100 Clichy, France.

[6 ] INSERM, UMR_S 938, Centre de Recherche Saint-Antoine, F-75012 Paris, France; UPMC, Univ Paris 06, UMR_S 938, Centre de Recherche Saint-Antoine, F-75012 Paris, France. Electronic address: laura.fouassier@inserm.fr.

Article

Publisher Item ID: S0168-8278(14)00214-1

DOI: 10.1016/j.jhep.2014.03.033

PubMed ID: 24704591

SO-VID: ce5af148-2fd5-4620-9333-d9e893127a1d

History

Keywords: Cholangiocarcinoma,E-cadherin,EGF,EGFR,Invasion,Migration

Data availability:

Keywords: Cholangiocarcinoma, E-cadherin, EGF, EGFR, Invasion, Migration

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