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      A new triazine based π-conjugated mesoporous 2D covalent organic framework: its in vitroanticancer activities

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          Abstract

          A new 2D π-conjugated COF, TrzCOF has been synthesized and it showed excellent anticancer activity for the colorectal carcinoma HCT-116 cell line.

          Abstract

          We report a new highly crystalline 2D π-conjugated hexagonal mesoporous covalent organic framework material, TrzCOF, through the solvothermal polycondensation of 1,3,5-tri(4-formylbiphenyl) benzene [Ph 7(CHO) 3, TFBPB] with 2,4,6-tris(4-aminophenyl)-1,3,5-triazine (TAPT) and it displayed excellent anticancer activity for human colorectal carcinoma HCT-116 cells.

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          Most cited references30

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          Porous, crystalline, covalent organic frameworks.

          Covalent organic frameworks (COFs) have been designed and successfully synthesized by condensation reactions of phenyl diboronic acid {C6H4[B(OH)2]2} and hexahydroxytriphenylene [C18H6(OH)6]. Powder x-ray diffraction studies of the highly crystalline products (C3H2BO)6.(C9H12)1 (COF-1) and C9H4BO2 (COF-5) revealed expanded porous graphitic layers that are either staggered (COF-1, P6(3)/mmc) or eclipsed (COF-5, P6/mmm). Their crystal structures are entirely held by strong bonds between B, C, and O atoms to form rigid porous architectures with pore sizes ranging from 7 to 27 angstroms. COF-1 and COF-5 exhibit high thermal stability (to temperatures up to 500 degrees to 600 degrees C), permanent porosity, and high surface areas (711 and 1590 square meters per gram, respectively).
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            Covalent organic frameworks (COFs): from design to applications.

            Covalent organic frameworks (COFs) represent an exciting new type of porous organic materials, which are ingeniously constructed with organic building units via strong covalent bonds. The well-defined crystalline porous structures together with tailored functionalities have offered the COF materials superior potential in diverse applications, such as gas storage, adsorption, optoelectricity, and catalysis. Since the seminal work of Yaghi and co-workers in 2005, the rapid development in this research area has attracted intensive interest from researchers with diverse expertise. This critical review describes the state-of-the-art development in the design, synthesis, characterisation, and application of the crystalline porous COF materials. Our own opinions on further development of the COF materials are also presented for discussion (155 references).
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              Cell cycle, CDKs and cancer: a changing paradigm.

              Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as genomic and chromosomal instability. According to current models, mammalian CDKs are essential for driving each cell cycle phase, so therapeutic strategies that block CDK activity are unlikely to selectively target tumour cells. However, recent genetic evidence has revealed that, whereas CDK1 is required for the cell cycle, interphase CDKs are only essential for proliferation of specialized cells. Emerging evidence suggests that tumour cells may also require specific interphase CDKs for proliferation. Thus, selective CDK inhibition may provide therapeutic benefit against certain human neoplasias.
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                Author and article information

                Contributors
                (View ORCID Profile)
                (View ORCID Profile)
                Journal
                CHCOFS
                Chemical Communications
                Chem. Commun.
                Royal Society of Chemistry (RSC)
                1359-7345
                1364-548X
                October 9 2018
                2018
                : 54
                : 81
                : 11475-11478
                Affiliations
                [1 ]Department of Materials Science, Indian Association for the Cultivation of Science Jadavpur
                [2 ]Kolkata – 700 032
                [3 ]India
                [4 ]Cancer Biology and Inflammatory Disorder Division
                [5 ]CSIR-Indian Institute of Chemical Biology, Jadavpur
                [6 ]Kolkata – 700032
                [7 ]Department of Chemistry
                [8 ]Indian Institute of Engineering Science and Technology, Shibpur
                [9 ]Howrah – 711103
                [10 ]Department of Ceramic
                [11 ]Nanomedicine & Tissue Engineering Laboratory
                [12 ]National Research Centre
                [13 ]El Bohouth St.
                [14 ]Dokki
                Article
                10.1039/C8CC07289B
                ce6c7446-3046-48fb-8af4-fd3fa398f665
                © 2018

                http://rsc.li/journals-terms-of-use

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